Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging.
cluster analysis
cortical thickness
mild cognitive impairment
neuropsychology
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
11
01
2020
revised:
13
03
2020
accepted:
23
03
2020
pubmed:
18
5
2020
medline:
2
6
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.
Identifiants
pubmed: 32418367
doi: 10.1002/alz.12108
pmc: PMC7383989
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1013-1022Subventions
Organisme : NIH HHS
ID : R01 NS097495
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG041851
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056366
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062429
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG011378
Pays : United States
Organisme : NIH HHS
ID : R01 AG041851
Pays : United States
Organisme : NIH HHS
ID : R01 AG056366
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097495
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG011378
Pays : United States
Organisme : NIH HHS
ID : R01 AG49810
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Organisme : NIH HHS
ID : R37 AG011378
Pays : United States
Organisme : NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049810
Pays : United States
Organisme : NIH HHS
ID : U01 AG06786
Pays : United States
Organisme : NIH HHS
ID : R01 AG034676
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
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