Temporal changes in FFR


Journal

Journal of cardiovascular computed tomography
ISSN: 1876-861X
Titre abrégé: J Cardiovasc Comput Tomogr
Pays: United States
ID NLM: 101308347

Informations de publication

Date de publication:
Historique:
received: 28 11 2019
revised: 09 04 2020
accepted: 27 04 2020
pubmed: 19 5 2020
medline: 7 4 2021
entrez: 19 5 2020
Statut: ppublish

Résumé

The ADVANCE registry is a large prospective study of outcomes and resource utilization in patients undergoing coronary computed tomography angiography (CCTA) and CT-based fractional flow reserve (FFR 5083 patients with coronary artery disease (CAD) on CCTA were prospectively enrolled in the ADVANCE registry and were divided into 3 equally sized cohorts based on the temporal order of enrollment per site. Demographics, CCTA and FFR The number of patients with a ≥70% stenosis on CCTA was similar over time (33.6%, 30.9%, and 33.8% for cohort 1-3). The rate of positive FFR Growing experience with FFR

Sections du résumé

BACKGROUND BACKGROUND
The ADVANCE registry is a large prospective study of outcomes and resource utilization in patients undergoing coronary computed tomography angiography (CCTA) and CT-based fractional flow reserve (FFR
METHODS METHODS
5083 patients with coronary artery disease (CAD) on CCTA were prospectively enrolled in the ADVANCE registry and were divided into 3 equally sized cohorts based on the temporal order of enrollment per site. Demographics, CCTA and FFR
RESULTS RESULTS
The number of patients with a ≥70% stenosis on CCTA was similar over time (33.6%, 30.9%, and 33.8% for cohort 1-3). The rate of positive FFR
CONCLUSIONS CONCLUSIONS
Growing experience with FFR

Identifiants

pubmed: 32418861
pii: S1934-5925(20)30143-X
doi: 10.1016/j.jcct.2020.04.011
pii:
doi:

Types de publication

Journal Article Multicenter Study Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

48-55

Informations de copyright

Copyright © 2020 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest Dr. Nous has received travel sponsorship from HeartFlow. Dr. Fairbairn has served on the Speakers Bureau for HeartFlow. Dr. Nørgaard has received unrestricted institutional research grants from Siemens and HeartFlow. Dr. Berman has received unrestricted research support from HeartFlow. Dr. Hurwitz-Koweek has received research support and fee as speaker from HeartFlow and Siemens. Dr. Pontone has received research grant and/or fee as speaker from GE Healthcare, Bracco, and HeartFlow. Dr. Budde has institutional research support from HeartFlow and Siemens Healthineers. Dr. Sonck has received research grant support from the Cardiopath PhD program. Dr. Rabbat has served as a consultant for HeartFlow. Dr. Mullen is an employee of and owns equity in HeartFlow. Dr. De Bruyne has received consulting fees from Abbott, Opsens, and Boston Scientific; and is a shareholder for Siemens, GE Healthcare, Bayer, Philips, HeartFlow, Edwards Lifesciences, and Sanofi. Dr. Rogers is employee of and owns equity in HeartFlow. Dr. Leipsic has served as a consultant for and owns stock options in Circle CVI and HeartFlow. Dr. Patel has received research grants from HeartFlow, Bayer, Janssen, and the National Heart, Lung, and Blood Institute; and has served on the advisory board for HeartFlow, Bayer, and Janssen. Dr. Nieman has received institutional research support from Siemens Healthineers, HeartFlow, GE Healthcare, and Bayer Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Auteurs

Fay Nous (F)

Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: f.nous@erasmusmc.nl.

Ricardo P J Budde (RPJ)

Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: r.budde@erasmusmc.nl.

Timothy A Fairbairn (TA)

Department of Cardiology, Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool, United Kingdom. Electronic address: timothy.fairbairn@lhch.nhs.uk.

Takashi Akasaka (T)

Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: akasat@wakayama-med.ac.jp.

Bjarne L Nørgaard (BL)

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: bnorgaard@dadlnet.dk.

Daniel S Berman (DS)

Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, CA, USA. Electronic address: daniel.berman@cshs.org.

Gilbert Raff (G)

Division of Cardiology, Beaumont Academic Heart and Vascular Group, Royal Oak, MI, USA. Electronic address: gilbert.raff@beaumont.edu.

Lynne M Hurwitz-Koweek (LM)

Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: lynne.koweek@duke.edu.

Gianluca Pontone (G)

Centro Cardiologico Monzino, IRCCS, Milan, Italy. Electronic address: gianluca.pontone@cardiologicomonzino.it.

Tomohiro Kawasaki (T)

Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan. Electronic address: to-kawasaki@mug.biglobe.ne.jp.

Niels Peter R Sand (NPR)

Cardiac Research Unit, Institute of Regional Health Research, University Hospital of Southern DK, Esbjerg and University of Southern DK, Denmark. Electronic address: npsand@webspeed.dk.

Jesper M Jensen (JM)

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: jespejns@rm.dk.

Tetsuya Amano (T)

Department of Cardiology, Aichi Medical University, Aichi, Japan. Electronic address: amanot@aichi-med-u.ac.jp.

Michael Poon (M)

Department of Noninvasive Cardiac Imaging, Northwell Health, New York, NY, USA. Electronic address: mpoon1@northwell.edu.

Kristian A Øvrehus (KA)

Department of Cardiology, Odense University Hospital, Denmark. Electronic address: kristian.altern.ovrehus@rsyd.dk.

Jeroen Sonck (J)

Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy. Electronic address: jeroensonck@icloud.com.

Mark G Rabbat (MG)

Division of Cardiology, Loyola University Chicago, Chicago, IL, USA. Electronic address: mrabbat@lumc.edu.

Sarah Mullen (S)

HeartFlow Inc., Redwood City, CA, USA. Electronic address: smullen@heartflow.com.

Bernard De Bruyne (B)

Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium. Electronic address: bernard.de.bruyne@olvz-aalst.be.

Campbell Rogers (C)

HeartFlow Inc., Redwood City, CA, USA. Electronic address: crogers@heartflow.com.

Hitoshi Matsuo (H)

Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan. Electronic address: matsuo@heart-center.or.jp.

Jeroen J Bax (JJ)

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: j.j.bax@lumc.nl.

Jonathon Leipsic (J)

Department of Radiology, Providence Health Care, St. Paul's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: jleipsic@providencehealth.bc.ca.

Manesh R Patel (MR)

Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: manesh.patel@duke.edu.

Koen Nieman (K)

Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA. Electronic address: knieman@stanford.edu.

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