Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly.
Aged
Aged, 80 and over
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/ genetics
Cognitive Dysfunction
/ diagnostic imaging
Female
Genetic Association Studies
/ methods
Genetic Variation
/ genetics
Germany
/ epidemiology
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
/ methods
Male
Memory
/ physiology
Middle Aged
Organ Size
/ physiology
Polymorphism, Single Nucleotide
/ genetics
CAMK2A
adults
elderly
hippocampus
logical memory
αCaMKII
Journal
Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
04
02
2020
revised:
31
03
2020
accepted:
03
05
2020
pubmed:
19
5
2020
medline:
30
9
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
Calcium/Calmodulin-dependent kinase alpha (αCaMKII) has been shown to play an essential role in synaptic plasticity and in learning and memory in animal models. However, there is little evidence for an involvement in specific memories in humans. Here we tested the potential involvement of the αCaMKII coding gene CAMK2A in verbal logical memory in two Caucasian populations from Germany, in a sample of 209 elderly people with cognitive impairments and a sample of 142 healthy adults. The association of single nucleotide polymorphisms (SNPs) located within the genomic region of CAMK2A with verbal logical memory learning and retrieval from the Wechsler Memory Scale was measured and hippocampal volume was assessed by structural MRI. In the elderly people, we found the minor allele of CAMK2A intronic SNP rs919741 to predict a higher hippocampal volume and better logical memory retrieval. This association was not found in healthy adults. The present study may provide evidence for an association of a genetic variant of the CAMK2A gene specifically with retrieval of logical memory in elderly humans. This effect is possibly mediated by a higher hippocampal volume.
Identifiants
pubmed: 32418901
pii: S0361-9230(20)30125-8
doi: 10.1016/j.brainresbull.2020.05.001
pii:
doi:
Substances chimiques
CAMK2A protein, human
EC 2.7.11.17
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-20Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.