Sentinel lymph node mapping of clinically N0 early oral cancer: a diagnostic pitfall on CT lymphography.
CT lymphography
Cervical lymph node metastasis
Early oral cancer
Sentinel lymph node
Journal
Oral radiology
ISSN: 1613-9674
Titre abrégé: Oral Radiol
Pays: Japan
ID NLM: 8806621
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
22
01
2020
accepted:
03
05
2020
pubmed:
19
5
2020
medline:
20
4
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
The purpose of this study was to reevaluate preoperative computed tomography lymphography (CTL) and enhanced CT images during follow-up to clarify whether SLNs enhanced by CTL were identified accurately before primary surgery with sentinel lymph node biopsy (SLNB) for clinically N0 early oral cancer. Thirty two early oral cancer patients without cervical lymph node metastasis were enrolled in this study. To clarify whether SLNs enhanced by CTL were identified accurately before primary surgery with SLNB, we reevaluated preoperative CTL and enhanced CT images during follow-up in all patients. SLNs were detected by CTL in 31 of 32 patients (96.9%). During follow-up after primary surgery with SLNB, 4 of 27 patients without SLN metastasis had occult neck metastasis. Of the 4 patients, only 1 patient with cancer of floor of the mouth had overlooking of SLN, and the overlooking rate of SLN was 3.1%. The overlooked small SLN (2.9 × 3.3 × 3.1 mm) was located at contralateral level IB. The CT numbers before, 2, 5, 10 min after iopamidol injection, were 33 HU, 37 HU, 62 HU, 52 HU, respectively. The CT numbers of overlooked SLN 5 and 10 min after the injection was higher than CT images scanned before the iopamidol injection. The enhancement of SLNs in CTL images after iopamidol injection should be compared sufficiently with CT images before iopamidol injection to avoid overlooking of SLNs in N0 early oral cancer.
Identifiants
pubmed: 32419102
doi: 10.1007/s11282-020-00442-1
pii: 10.1007/s11282-020-00442-1
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
251-255Références
Hanai N, Asakage T, Kiyota N, Homma A, Hayashi R. Controversies in relation to neck management in N0 early oral tongue cancer. Jpn J Clin Oncol. 2019;49:297–305.
doi: 10.1093/jjco/hyy196
Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg. 1990;160:405–9.
doi: 10.1016/S0002-9610(05)80554-9
Byers RM, Weber RS, Andrews T, McGill D, Kare R, Wolf P. Frequency and therapeutic implications of “skip metastases” in the neck from squamous cell carcinoma of the oral tongue. Head Neck. 1997;19:14–9.
doi: 10.1002/(SICI)1097-0347(199701)19:1<14::AID-HED3>3.0.CO;2-Y
Honda K, Ishiyama K, Suzuki S, Oumi E, Sato T, Kawasaki Y, et al. Sentinel lymph node biopsy using computed tomographic lymphography in patients with early tongue cancer. Acta Otolaryngol. 2015;135:507–12.
doi: 10.3109/00016489.2015.1010126
Morton DL, Bostick PJ. Will the true sentinel node please stand? Ann Surg Oncol. 1999;6:12–4.
doi: 10.1007/s10434-999-0012-9
Rigual N, Loree T, Frustino J, Jayaprakash V, Cohan D, Sullivan M, et al. Sentinel node biopsy in lieu of neck dissection for staging oral cancer. JAMA Otolaryngol Head Neck Surg. 2013;139:779–82.
doi: 10.1001/jamaoto.2013.3863
Bilde A, von Buchwald C, Therkildsen MH, Mortensen J, Kirkegaard J, Charabi B, et al. Need for intensive histopathologic analysis to determine lymph node metastases when using sentinel node biopsy in oral cancer. Laryngoscope. 2008;118:408–14.
doi: 10.1097/MLG.0b013e31815d8e15
Bredell MG. Sentinel lymph node mapping by indocyanine green fluorescence imaging in oropharyngeal cancer—preliminary experience. Head Neck Oncol. 2010;2:3.
doi: 10.1186/1758-3284-2-31
Iwai T, Maegawa J, Hirota M, Tohnai I. Sentinel lymph node biopsy using a new indocyanine green fluorescence imaging system with a color charged couple device camera for oral cancer. Br J Oral Maxillofac Surg. 2013;51:e26–e2828.
doi: 10.1016/j.bjoms.2012.03.002
Miura K, Hirakawa H, Uemura H, Yoshimoto S, Shiotani A, Sugasawa M, et al. Sentinel node biopsy for oral cancer: a prospective multicenter phase II trial. Auris Nasus Larynx. 2017;44:319–26.
doi: 10.1016/j.anl.2016.07.008
Den Toom IJ, Heuveling DA, Flach GB, Van Weert S, Karagozoglu KH, Van Schie A, et al. Sentinel node biopsy for early oral cavity cancer: the VU University Medical Center experience. Head Neck. 2015;37:573–8.
doi: 10.1002/hed.23632
Pedersen NJ, Hebbelstrup Jensen D, Hedbäck N, Frendø M, Kiss K, et al. Staging of early lymph node metastases with the sentinel lymph node technique and predictive factors in T1/T2 oral cavity cancer: a retrospective single-center study. Head Neck. 2016;38:E1033–E10401040.
doi: 10.1002/hed.24153
den Toom IJ, van Schie A, van Weert S, Karagozoglu KH, Bloemena E, Hoekstra OS, et al. The added value of SPECT-CT for the identification of sentinel lymph nodes in early stage oral cancer. Eur J Nucl Med Mol Imaging. 2017;44:998–1004.
doi: 10.1007/s00259-017-3613-8
Abdul-Razak M, Chung H, Wong E, Palme C, Veness M, Farlow D, et al. Sentinel lymph node biopsy for early oral cancers: Westmead Hospital experience. ANZ J Surg. 2017;87:65–9.
doi: 10.1111/ans.13853
Khafif A, Schneebaum S, Fliss DM, Lerman H, Metser U, Ben-Yosef R, et al. Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma. Head Neck. 2006;28:874–9.
doi: 10.1002/hed.20434
Alkureishi LW, Ross GL, Shoaib T, Soutar DS, Robertson AG, Thompson R, et al. Sentinel node biopsy in head and neck squamous cell cancer: 5-year follow-up of a European multicenter trial. Ann Surg Oncol. 2010;17:2459–64.
doi: 10.1245/s10434-010-1111-3
Mokhtar M, Tadokoro Y, Nakagawa M, Morimoto M, Takechi H, Kondo K, et al. Triple assessment of sentinel lymph node metastasis in early breast cancer using preoperative CTLG, intraoperative fluorescence navigation and OSNA. Breast Cancer. 2016;23:202–10.
doi: 10.1007/s12282-014-0551-1
Yamamoto S, Suga K, Maeda K, Maeda N, Yoshimura K, Oka M. Breast sentinel lymph node navigation with three-dimensional computed tomography-lymphography: a 12-year study. Breast Cancer. 2016;23:456–62.
doi: 10.1007/s12282-015-0584-0
Nakagawa M, Morimoto M, Takechi H, Tadokoro Y, Tangoku A. Preoperative diagnosis of sentinel lymph node (SLN) metastasis using 3D CT lymphography (CTLG). Breast Cancer. 2016;23:519–24.
doi: 10.1007/s12282-015-0597-8
Yasuta M, Sato S, Ishida T, Kiyohara T. Usefulness of CT-lymphography in sentinel lymph node navigation. Int J Clin Oncol. 2014;19:557–62.
doi: 10.1007/s10147-013-0582-1
Yuasa Y, Seike J, Yoshida T, Takechi H, Yamai H, Yamamoto Y, et al. Sentinel lymph node biopsy using intraoperative indocyanine green fluorescence imaging navigated with preoperative CT lymphography for superficial esophageal cancer. Ann Surg Oncol. 2012;19:486–93.
doi: 10.1245/s10434-011-1922-x
Yoshida Y, Adachi K, Nakashima K, Yamane T, Yamamoto O. Difficulty to identify sentinel lymph nodes with computed tomography-lymphography in patients with cutaneous melanoma. Acta Derm Venereol. 2011;91:465–6.
doi: 10.2340/00015555-1057
Tsujimoto H, Yaguchi Y, Sakamoto N, Kumano I, Takahata R, Matsumoto Y, et al. Computed tomography lymphography for the detection of sentinel nodes in patients with gastric carcinoma. Cancer Sci. 2010;101:2586–90.
doi: 10.1111/j.1349-7006.2010.01706.x
Saito M, Nishiyama H, Oda Y, Shingaki S, Hayashi T. The lingual lymph node identified as a sentinel node on CT lymphography in a patient with cN0 squamous cell carcinoma of the tongue. Dentomaxillofac Radiol. 2012;41:254–8.
doi: 10.1259/dmfr/61883763
Sugiyama S, Iwai T, Izumi T, Ishiguro K, Baba J, Oguri S, et al. CT lymphography for sentinel lymph node mapping of clinically N0 early oral cancer. Cancer Imaging. 2019;19:72.
doi: 10.1186/s40644-019-0258-9
Honda K, Ishiyama K, Suzuki S, Kawasaki Y, Saito H, Horii A. Sentinel lymph node biopsy using preoperative computed tomographic lymphography and intraoperative indocyanine green fluorescence imaging in patients with localized tongue cancer. JAMA Otolaryngol Head Neck Surg. 2019;145:735–40.
doi: 10.1001/jamaoto.2019.1243
Mølstrøm J, Grønne M, Green A, Bakholdt V, Sørensen JA. Topographical distribution of sentinel nodes and metastases from T1–T2 oral squamous cell carcinomas. Eur J Cancer. 2019;107:86–92.
doi: 10.1016/j.ejca.2018.10.021
Bredell MG. Sentinel lymph node mapping by indocyanine green fluorescence imaging in oropharyngeal cancer—preliminary experience. Head Neck Oncol. 2010;2:31.
doi: 10.1186/1758-3284-2-31
Peng H, Wang SJ, Niu X, Yang X, Chi C, Zhang G. Sentinel node biopsy using indocyanine green in oral/oropharyngeal cancer. World J Surg Oncol. 2015;13:278.
doi: 10.1186/s12957-015-0691-6
Al-Dam A, Precht C, Barbe A, Kohlmeier C, Hanken H, Wikner J, et al. Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using indocyanine green fluorescence imaging. J Craniomaxillofac Surg. 2018;46:1379–84.
doi: 10.1016/j.jcms.2018.05.039
van der Vorst JR, Schaafsma BE, Verbeek FP, Keereweer S, Jansen JC, van der Velden LA, et al. Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients. Oral Oncol. 2013;49:15–9.
doi: 10.1016/j.oraloncology.2012.07.017
Fang Q, Li P, Qi J, Luo R, Chen D, Zhang X. Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue. Laryngoscope. 2019;129:2527–30.
doi: 10.1002/lary.27927
Jia J, Jia MQ, Zou HX. Lingual lymph nodes in patients with squamous cell carcinoma of the tongue and the floor of the mouth. Head Neck. 2018;40:2383–8.
doi: 10.1002/hed.25340
Ananian SG, Gvetadze SR, Ilkaev KD, Mochalnikova VV, Zayratiants GO, Mkhitarov VA, et al. Anatomic-histologic study of the floor of the mouth: the lingual lymph nodes. Jpn J Clin Oncol. 2015;45:547–54.
pubmed: 25770836
Ando M, Asai M, Ono T, Nakanishi Y, Asakage T, Yamasoba T. Metastases to the lingual nodes in tongue cancer: a pitfall in a conventional neck dissection. Auris Nasus Larynx. 2010;37:386–9.
doi: 10.1016/j.anl.2009.10.001
Ozeki S, Tashiro H, Okamoto M, Matsushima T. Metastasis to the lingual lymph node in carcinoma of the tongue. J Maxillofac Surg. 1985;13:277–81.
doi: 10.1016/S0301-0503(85)80064-3
Dutton JM, Graham SM, Hoffman HT. Metastatic cancer to the floor of mouth: the lingual lymph nodes. Head Neck. 2002;24:401–5.
doi: 10.1002/hed.10026
Umeda M, Minamikawa T, Shigeta T, Oguni A, Kataoka T, Takahashi H, et al. Metastasis to the lingual lymph node in patients with squamous cell carcinoma of the floor of the mouth: a report of two cases. Kobe J Med Sci. 2010;55:E67–72.
pubmed: 20847593
Nishio N, Fujimoto Y, Hiramatsu M, Yamamoto Y, Sone M. Sonographic detection of a lingual node metastasis from early squamous cell cancer of the tongue. J Clin Ultrasound. 2018;46:69–72.
doi: 10.1002/jcu.22486
Han W, Yang X, Huang X, Hu Q, Wang Z. Metastases to lingual lymph nodes from squamous cell carcinoma of the tongue. Br J Oral Maxillofac Surg. 2008;46:376–8.
doi: 10.1016/j.bjoms.2007.12.002