Serum metabolomics reveals the intervention mechanism and compatible regularity of Chaihu Shu Gan San on chronic unpredictable mild stress-induced depression rat model.
Animals
Antidepressive Agents
/ pharmacology
Behavior, Animal
/ drug effects
Biomarkers
/ blood
Chromatography, Liquid
Depression
/ blood
Disease Models, Animal
Energy Metabolism
/ drug effects
Male
Metabolomics
Plant Extracts
/ pharmacology
Rats, Sprague-Dawley
Spectrometry, Mass, Electrospray Ionization
Stress, Psychological
/ complications
Chaihu Shu Gan San
antidepression
chronic unpredictable mild stress-induced depression
compatibility
serum metabolomics
ultra-performance liquid chromatography quadrupole/time-of-flight mass spectrometry
Journal
The Journal of pharmacy and pharmacology
ISSN: 2042-7158
Titre abrégé: J Pharm Pharmacol
Pays: England
ID NLM: 0376363
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
01
12
2019
accepted:
04
04
2020
pubmed:
19
5
2020
medline:
14
4
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
To provide a comprehensive study of the intervention mechanism and compatible regularity of Chaihu Shu Gan San (CSGS) in a chronic unpredictable mild stress (CUMS)-induced depression model. Ethological study and ELISA assay were applied to measure the phenotypes of depression after CUMS stimulate and assess the antidepressant activity of fluoxetine, CSGS and its compatibilities. The serum metabolic profile changes were revealed by untargeted Q/TOF MS-based metabolomics followed by multivariate statistical analysis. CSGS exhibits an significant intervention effect on CUMS-induced depression. After the multivariate statistical analysis, 17 potential serum biomarkers were identified and 16 of them could be regulated by CSGS. The intervention of CSGS on CUMS-induced depression involved five key pathways. Moreover, each functional unit (monarch, minister, assistant and guide medicine) in CSGS regulates different metabolites and metabolic pathways to achieve different effects on antidepressant; however, their intervention efficacies are inferior to the holistic formula, which may be due to the synergism of bioactive ingredients in the seven herbs of CSGS. CSGS produced an obvious antidepressant activity. The comprehensive and holistic metabolomics approach could be a powerful tool to study the intervention mechanism and the compatibility rule of traditional Chinese medicine.
Substances chimiques
Antidepressive Agents
0
Biomarkers
0
Plant Extracts
0
chaihu-shugan-san
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1133-1143Subventions
Organisme : Youth Science Foundation of Guangxi Medical University
ID : GXMUYSF13
Organisme : Youth Science Foundation of Guangxi Medical University
ID : GXMUYSF18
Organisme : Guangxi First-class Discipline Project for Pharmaceutical Sciences
ID : GXFCDP-PS-2018
Organisme : National Natural Science Foundation of China
ID : 81360638
Organisme : National Natural Science Foundation of China
ID : 81560626
Organisme : National Natural Science Foundation of China
ID : 81603533
Organisme : the National Training Programs of Innovation and Entrepreneurship for Undergraduates of China
ID : 201410598010
Organisme : Pharmaceutical Postgraduate Joint Cultivation Base for Inovation & Entrepreneurship
ID : 20170703
Organisme : Natural Science Foundation of Guangxi Province
ID : 2012GXNSFBA053108
Organisme : Natural Science Foundation of Guangxi Province
ID : 2013GXNSFAA019161
Organisme : program for Scientific Research in Guangxi Higher Education Institutions
ID : 200103YB026
Informations de copyright
© 2020 Royal Pharmaceutical Society.
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