Spindle checkpoint: trapped by the corona, cyclin B1 goes MAD.
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
17 06 2020
17 06 2020
Historique:
pubmed:
19
5
2020
medline:
2
4
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
The spindle checkpoint protects against aneuploidy by ensuring that dividing cells only proceed with chromosome segregation once all kinetochores are stably attached to spindle microtubules. The checkpoint protein MAD1 localizes to the corona, a structural expansion of the kinetochore forming in the absence of microtubule attachment, but molecular mechanism or functional significance of this localization remains unknown. Recent results now show that cyclin B1 recruits MAD1 to the corona and that this MAD1 pool is required for robust checkpoint signaling.
Identifiants
pubmed: 32419215
doi: 10.15252/embj.2020105279
pmc: PMC7298284
doi:
Substances chimiques
Cell Cycle Proteins
0
Cyclin B1
0
Types de publication
News
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e105279Subventions
Organisme : Cancer Research UK
ID : 32202322
Pays : United Kingdom
Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2020 The Authors.
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