Is there an association between viral load, CD4 count, WHO staging, and dental caries in HIV-positive children?
HIV/AIDS
biomarkers
caries detection/diagnosis/prevention
child Dentistry
epidemiology
paediatric dentistry
Journal
International journal of paediatric dentistry
ISSN: 1365-263X
Titre abrégé: Int J Paediatr Dent
Pays: England
ID NLM: 9107511
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
10
2019
revised:
28
04
2020
accepted:
29
04
2020
pubmed:
19
5
2020
medline:
2
3
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
Few studies have investigated an association between CD4 counts, viral load (VL), WHO staging, and caries among HIV-positive (HIV+) children on HAART therapy (>12 months). To determine the strength of association between CD4 counts, WHO staging, VL, and dental caries. This cross-sectional analytical study comprised of 355 HIV + children, aged 4-12 years, attending a hospital in Johannesburg, South Africa. Demographic and clinical data such as decayed (d,D), missing (m,M), filled teeth (f,F) [dmft/DMFT], CD4 counts, and WHO staging were collected. Correlation and regression analyses were done to test for associations. Caries prevalence for this cohort of children was 57%. The dmft score for the primary dentition was 4.36 (SD 4.87) and DMFT for secondary dentition was 0.58 (SD 1.49). Pearson's correlation analyses showed significant association between VL and CD4 count (P = .003) and VL and WHO stage (P = .007). Weak associations were noted between caries (d, D) and VL, CD4 count, and WHO stage of disease for correlation and regression analyses. There appears to be no substantial evidence of any significant association between the presence of caries among HIV + children and CD4 counts, viral load, and WHO clinical stage of the disease.
Sections du résumé
BACKGROUND
BACKGROUND
Few studies have investigated an association between CD4 counts, viral load (VL), WHO staging, and caries among HIV-positive (HIV+) children on HAART therapy (>12 months).
AIM
OBJECTIVE
To determine the strength of association between CD4 counts, WHO staging, VL, and dental caries.
DESIGN
METHODS
This cross-sectional analytical study comprised of 355 HIV + children, aged 4-12 years, attending a hospital in Johannesburg, South Africa. Demographic and clinical data such as decayed (d,D), missing (m,M), filled teeth (f,F) [dmft/DMFT], CD4 counts, and WHO staging were collected. Correlation and regression analyses were done to test for associations.
RESULTS
RESULTS
Caries prevalence for this cohort of children was 57%. The dmft score for the primary dentition was 4.36 (SD 4.87) and DMFT for secondary dentition was 0.58 (SD 1.49). Pearson's correlation analyses showed significant association between VL and CD4 count (P = .003) and VL and WHO stage (P = .007). Weak associations were noted between caries (d, D) and VL, CD4 count, and WHO stage of disease for correlation and regression analyses.
CONCLUSION
CONCLUSIONS
There appears to be no substantial evidence of any significant association between the presence of caries among HIV + children and CD4 counts, viral load, and WHO clinical stage of the disease.
Types de publication
Journal Article
Langues
eng
Pagination
231-237Informations de copyright
© 2020 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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