Novel
Anaplastic lymphoma receptor tyrosine kinase (ALK)
fluorescence in situ hybridization (FISH)
immunohistochemistry (IHC)
lung adenocarcinoma
mRNA in situ hybridization (mRNA-ISH)
Journal
Translational lung cancer research
ISSN: 2218-6751
Titre abrégé: Transl Lung Cancer Res
Pays: China
ID NLM: 101646875
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
19
5
2020
pubmed:
19
5
2020
medline:
19
5
2020
Statut:
ppublish
Résumé
A recent technical advance in mRNA The study included 279 surgically resected lung adenocarcinomas and 44 transbronchial-biopsied (TBB) adenocarcinomas. mRNA-ISH was conducted using the RNAscope 2.0 system, which includes pre-designed probes for detecting the tyrosine kinase domain encoded in ALK protein expression was detected in 11 of 279 specimens (3.9%). The
Sections du résumé
BACKGROUND
BACKGROUND
A recent technical advance in mRNA
METHODS
METHODS
The study included 279 surgically resected lung adenocarcinomas and 44 transbronchial-biopsied (TBB) adenocarcinomas. mRNA-ISH was conducted using the RNAscope 2.0 system, which includes pre-designed probes for detecting the tyrosine kinase domain encoded in
RESULTS
RESULTS
ALK protein expression was detected in 11 of 279 specimens (3.9%).
CONCLUSIONS
CONCLUSIONS
The
Identifiants
pubmed: 32420065
doi: 10.21037/tlcr.2020.03.04
pii: tlcr-09-02-257
pmc: PMC7225155
doi:
Types de publication
Journal Article
Langues
eng
Pagination
257-268Informations de copyright
2020 Translational Lung Cancer Research. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tlcr.2020.03.04). The authors have no conflicts of interest to declare.
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