Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2.
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
10
2019
revised:
06
01
2020
accepted:
16
01
2020
entrez:
19
5
2020
pubmed:
19
5
2020
medline:
11
2
2021
Statut:
epublish
Résumé
Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underlying the changes in miRNAs expression and the regulation of miRNAs functions have not been well clarified. In this study, we found that the expression of miR-30b-5p was upregulated in breast cancer tissues and breast cancer cell lines, compared to paracancer tissues and normal breast cell lines. Moreover, induced overexpression of miR-30b-5p promoted the MDA-MB-231 and HCC 1937 cell growth, migration, and invasion and reduced the cellular apoptosis. Further studies confirmed that miR-30b-5p could directly target ASPP2 and then activate the AKT signaling pathway. Our results suggested that miR-30b-5p could act as a tumor promoter in TNBC. The newly identified miR-30b-5p/ASPP2/AKT axis represents a novel therapeutic strategy for treating TNBC.
Identifiants
pubmed: 32420372
doi: 10.1155/2020/7907269
pmc: PMC7210518
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
MIRN30b microRNA, human
0
MicroRNAs
0
Neoplasm Proteins
0
RNA, Neoplasm
0
TP53BP2 protein, human
0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7907269Informations de copyright
Copyright © 2020 Tianqi Wu et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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