ACLY is the novel signaling target of PIP
ACLY
Acetyl-CoA
Biochemistry
Biological sciences
Cancer
Cancer research
Health sciences
Lyn
Metabolism
PI3K
Src
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
21
04
2020
revised:
26
04
2020
accepted:
29
04
2020
entrez:
19
5
2020
pubmed:
19
5
2020
medline:
19
5
2020
Statut:
epublish
Résumé
A fundamental feature of tumor progression is reprogramming of metabolic pathways. ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The phosphoinositide 3-kinase (PI3K) and Src-family kinase (SFK) Lyn are constitutively activate in many cancers. We show here, for the first time, that both the substrate and product of PI3K, phosphatidylinositol-(4,5)-bisphosphate (PIP
Identifiants
pubmed: 32420483
doi: 10.1016/j.heliyon.2020.e03910
pii: S2405-8440(20)30755-6
pii: e03910
pmc: PMC7218026
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e03910Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM127631
Pays : United States
Informations de copyright
© 2020 The Author(s).
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