A thermodynamic insight into viral infections: do viruses in a lytic cycle hijack cell metabolism due to their low Gibbs energy?
Biophysical chemistry
Biophysics
Chemical reaction kinetics
Gibbs free energy of growth
Growth rate
Growth reaction
Microbiology
Organism empirical formula
Thermodynamics
Virology
Virus
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
07
02
2020
revised:
02
03
2020
accepted:
01
05
2020
entrez:
19
5
2020
pubmed:
19
5
2020
medline:
19
5
2020
Statut:
epublish
Résumé
After adsorption and penetration, a virus hijacks a cell's metabolic machinery and uses it as a medium for its reproduction and growth through multiplication. Growth is competitive, since the same precursors and machinery are used by both the virus and its host cell. But what drives a virus to perform its life cycle more efficiently than its host? Gibbs energy represents the driving force for all chemical reactions in nature. Therefore, hypothetically Gibbs energy of growth can represent the driving force of viral lytic cycle. After chemical characterization of 17 viruses and their hosts, in this paper, growth reactions were suggested, and enthalpy, entropy and Gibbs free energy of both formation and growth were calculated. By comparing the Gibbs energy of growth of viruses and their hosts, it has been found that a virus always has a more negative Gibbs free energy of growth than its host implying that synthesis of viral components is more thermodynamically favorable. Thus, it seems that the physical laws explain observed biological phenomena - the hijack of host life machinery and high efficiency of virus growth.
Identifiants
pubmed: 32420495
doi: 10.1016/j.heliyon.2020.e03933
pii: S2405-8440(20)30778-7
pii: e03933
pmc: PMC7218021
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e03933Informations de copyright
© 2020 The Authors.
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