Acute high-dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice.
Firmicutes
IL-4
Lactobacillus species
TiO2 nanoparticles
gastrointestinal tract
mucin-2
segmented filamentous bacteria
weight gain
Journal
Journal of applied toxicology : JAT
ISSN: 1099-1263
Titre abrégé: J Appl Toxicol
Pays: England
ID NLM: 8109495
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
30
01
2020
revised:
10
03
2020
accepted:
04
04
2020
pubmed:
19
5
2020
medline:
3
11
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
Human exposure to a wide variety of engineered nanoparticles (NPs) is on the rise and use in common food additives increases gastrointestinal (GI) exposure. Host health is intricately linked to the GI microbiome and immune response. Perturbations in the microbiota can affect energy harvest, trigger inflammation and alter the mucosal barrier leading to various disease states such as obesity and inflammatory bowel diseases. We hypothesized that single high-dose titanium dioxide (TiO
Substances chimiques
Coloring Agents
0
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1384-1395Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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