Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus.
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
pubmed:
19
5
2020
medline:
3
2
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
The critical role of suppressive myeloid cells in immune regulation has come to the forefront in cancer research, with myeloid-derived suppressor cells (MDSCs) as a main oncology immunotherapeutic target. Recent improvement and standardization of criteria classifying tumor-induced MDSCs have led to unified descriptions and also promoted MDSC research in tuberculosis (TB) and AIDS. Despite convincing evidence on the induction of MDSCs by pathogen-derived molecules and inflammatory mediators in TB and AIDS, very little attention has been given to their therapeutic modulation or roles in vaccination in these diseases. Clinical manifestations in TB are consequences of complex host-pathogen interactions and are substantially affected by HIV infection. Here we summarize the current understanding and knowledge gaps regarding the role of MDSCs in HIV and Mycobacterium tuberculosis (co)infections. We discuss key scientific priorities to enable application of this knowledge to the development of novel strategies to improve vaccine efficacy and/or implementation of enhanced treatment approaches. Building on recent findings and potential for cross-fertilization between oncology and infection biology, we highlight current challenges and untapped opportunities for translating new advances in MDSC research into clinical applications for TB and AIDS.
Identifiants
pubmed: 32420917
pii: 136288
doi: 10.1172/JCI136288
pmc: PMC7260010
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2789-2799Subventions
Organisme : NIAID NIH HHS
ID : R21 AI127132
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI130595
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI037856
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201600001G
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201600001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133190
Pays : United States
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