Stem Cells in Liver Fibrosis: Translational Challenges and Opportunities.

The liver is a vital organ with high regenerative ability that compensates cellular loss in liver injury. However, in chronic injuries ECM accumulates and leads to loss of cells and normal function. Liver transplantation is an effective therapy for patients with liver failure, but because of a lack of liver donors, research focus has moved toward the use of stem cells to regenerate the liver. This review emphasizes the potential of different types of stem cell to be used in liver regeneration.