Two-Faced Roles of Tumor-Associated Neutrophils in Cancer Development and Progression.
CXCR2
CXCR4
chemokine
granulocyte-colony stimulating factor (G–CSF), interleukin-17
myeloid-derived suppressor cell
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 May 2020
14 May 2020
Historique:
received:
24
04
2020
revised:
11
05
2020
accepted:
13
05
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
12
2
2021
Statut:
epublish
Résumé
Neutrophils are the most abundant circulating leukocytes in humans. Neutrophil infiltration into tumor tissues has long been observed but its roles have been ignored due to the presumed short life cycle and metabolic incompetence of neutrophils. Recent advances in neutrophil biology research have revealed that neutrophils have a longer life cycle with a potential to express various bioactive molecules. Clinical studies have simultaneously unraveled an increase in the neutrophil-lymphocyte ratio (NLR), a ratio of absolute neutrophil to absolute lymphocyte numbers in cancer patient peripheral blood and an association of higher NLR with more advanced or aggressive disease. As a consequence, tumor-associated neutrophils (TANs) have emerged as important players in tumor microenvironment. The elucidation of the roles of TANs, however, has been hampered by their multitude of plasticity in terms of phenotypes and functionality. Difficulties are further enhanced by the presence of a related cell population-polymorphonuclear leukocyte (PMN)-myeloid-derived suppressor cells (MDSCs)-and various dissimilar aspects of neutrophil biology between humans and mice. Here, we discuss TAN biology in various tumorigenesis processes, and particularly focus on the context-dependent functional heterogeneity of TANs.
Identifiants
pubmed: 32422991
pii: ijms21103457
doi: 10.3390/ijms21103457
pmc: PMC7278934
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japanese Agency for Medical Research and Development
ID : 20fk021007hh001
Organisme : Japan Society for the Promotion of Sciences
ID : 20K07567
Références
J Exp Med. 2017 May 1;214(5):1333-1350
pubmed: 28424248
J Clin Invest. 2014 Dec;124(12):5466-80
pubmed: 25384214
Int J Cancer. 2015 Feb 1;136(3):572-83
pubmed: 24806531
Cancer Cell. 2016 Jun 13;29(6):832-845
pubmed: 27265504
Cell. 2019 Mar 7;176(6):1248-1264
pubmed: 30849371
Cancer Res. 2003 Mar 15;63(6):1405-12
pubmed: 12649206
Hepatology. 2015 Jan;61(1):238-48
pubmed: 25131778
Cancer Res. 2019 Dec 15;79(24):6067-6073
pubmed: 31527091
Cancer Res. 1990 Oct 1;50(19):6243-7
pubmed: 2119251
Gastroenterology. 2019 Apr;156(5):1467-1482
pubmed: 30550822
Clin Cancer Res. 2017 May 1;23(9):2346-2355
pubmed: 27799249
Pigment Cell Melanoma Res. 2020 Jan;33(1):63-73
pubmed: 31402559
Cell Rep. 2018 Jun 26;23(13):3946-3959.e6
pubmed: 29949776
Cell. 2017 Feb 9;168(4):670-691
pubmed: 28187288
J Clin Invest. 1976 Sep;58(3):705-15
pubmed: 956397
J Immunol. 2020 Apr 15;204(8):2285-2294
pubmed: 32169849
Blood. 2007 Oct 15;110(8):2965-73
pubmed: 17562875
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10455-10460
pubmed: 28900008
Clin Cancer Res. 2019 Mar 15;25(6):1957-1969
pubmed: 30482778
Clin Cancer Res. 2009 Apr 15;15(8):2675-84
pubmed: 19336519
Trends Immunol. 2019 Jul;40(7):584-597
pubmed: 31153737
Cancer Res. 2010 Aug 1;70(15):6139-49
pubmed: 20631080
Cancer Metastasis Rev. 2009 Dec;28(3-4):345-53
pubmed: 19967427
Science. 2016 Apr 8;352(6282):175-80
pubmed: 27124451
J Immunol. 2004 Apr 15;172(8):5034-40
pubmed: 15067085
Hepatology. 2019 Oct;70(4):1214-1230
pubmed: 30933361
Tumour Biol. 2015 Sep;36(10):7789-96
pubmed: 25944163
Int J Cancer. 2015 Aug 15;137(4):837-47
pubmed: 25604426
Nat Cell Biol. 2020 Apr;22(4):465-475
pubmed: 32203421
Semin Cell Dev Biol. 2018 Jun;78:51-61
pubmed: 28779979
Trends Immunol. 2010 Aug;31(8):318-24
pubmed: 20620114
Pathobiology. 1990;58(5):249-64
pubmed: 2076189
Nat Rev Immunol. 2018 Dec;18(12):773-789
pubmed: 30254251
Physiol Rev. 2018 Apr 1;98(2):1055-1082
pubmed: 29537336
J Leukoc Biol. 2015 Jan;97(1):39-47
pubmed: 25416815
Nat Rev Immunol. 2013 Mar;13(3):159-75
pubmed: 23435331
Lung Cancer. 2013 Sep;81(3):468-474
pubmed: 23850196
J Exp Med. 2019 Jan 7;216(1):176-194
pubmed: 30567719
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21248-55
pubmed: 21081700
Int J Cancer. 2016 Apr 15;138(8):1982-93
pubmed: 26619320
Trends Immunol. 2007 Aug;28(8):340-5
pubmed: 17627888
Immunol Today. 1992 May;13(5):169-72
pubmed: 1642755
PLoS One. 2014 Jun 06;9(6):e98259
pubmed: 24906014
J Leukoc Biol. 2003 Mar;73(3):363-8
pubmed: 12629150
Int J Cancer. 2009 Aug 15;125(4):887-93
pubmed: 19431148
PLoS One. 2017 Dec 6;12(12):e0188799
pubmed: 29211768
Sci Transl Med. 2016 Oct 19;8(361):361ra138
pubmed: 27798263
Clin Cancer Res. 2019 May 1;25(9):2887-2899
pubmed: 30705034
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11300-11305
pubmed: 27651484
Nat Med. 2017 Oct 6;23(10):1124-1134
pubmed: 28985214
Blood. 2019 May 16;133(20):2178-2185
pubmed: 30898862
Nat Med. 2015 Aug;21(8):938-945
pubmed: 26193342
Neuro Oncol. 2016 Sep;18(9):1253-64
pubmed: 27006175
Curr Drug Targets. 2015;16(4):284-94
pubmed: 25342597
Cancer Cell. 2019 Apr 15;35(4):559-572.e7
pubmed: 30905761
Oncogene. 2017 Jul 13;36(28):4001-4013
pubmed: 28288136
Nat Med. 2010 Feb;16(2):219-23
pubmed: 20081861
J Natl Cancer Inst. 2012 Nov 7;104(21):1635-46
pubmed: 23104212
Trends Immunol. 2019 Jul;40(7):598-612
pubmed: 31256783
Nat Rev Immunol. 2016 May 27;16(6):378-91
pubmed: 27231052
PLoS One. 2019 Jan 28;14(1):e0211041
pubmed: 30689655
J Exp Med. 1993 Jul 1;178(1):151-61
pubmed: 7686211
Oncotarget. 2018 Jun 19;9(47):28364-28378
pubmed: 29983866
J Cell Sci. 1997 Apr;110 ( Pt 7):871-9
pubmed: 9133674
Nat Cell Biol. 2017 Apr;19(4):271-281
pubmed: 28319093
Growth Factors. 2009 Dec;27(6):335-44
pubmed: 19919521
Oncotarget. 2016 Dec 20;7(51):85185-85195
pubmed: 27835905
Cancer Cell. 2016 Jul 11;30(1):120-135
pubmed: 27374224
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6742-7
pubmed: 19346489
Oncotarget. 2016 Nov 1;7(44):72184-72196
pubmed: 27708229
Oncoimmunology. 2016 Feb 18;5(5):e1134073
pubmed: 27467952
Cancer Res. 2018 May 15;78(10):2680-2690
pubmed: 29490946
J Exp Med. 2017 Jul 3;214(7):1861-1876
pubmed: 28630089
Mol Cancer Ther. 2018 Jul;17(7):1515-1525
pubmed: 29643149
J Immunol. 1984 Dec;133(6):3291-7
pubmed: 6092470
Nature. 2015 Jun 18;522(7556):349-53
pubmed: 25985180
J Immunol Methods. 1999 Dec 17;232(1-2):121-9
pubmed: 10618514
J Immunol Res. 2017;2017:9671604
pubmed: 28299345
Nature. 2019 Feb;566(7745):553-557
pubmed: 30728496
Cancer Cell. 2016 Aug 8;30(2):243-256
pubmed: 27505671
Nat Rev Immunol. 2019 Apr;19(4):255-265
pubmed: 30816340
Blood. 2011 Jan 27;117(4):1196-204
pubmed: 21051556
Transl Oncol. 2015 Feb;8(1):18-24
pubmed: 25749173
J Clin Invest. 2008 Feb;118(2):560-70
pubmed: 18219394
Front Oncol. 2019 Dec 06;9:1370
pubmed: 31921634
Blood. 1992 Mar 15;79(6):1484-90
pubmed: 1347707
J Clin Invest. 2012 Sep;122(9):3127-44
pubmed: 22922255
Oncoimmunology. 2013 Feb 1;2(2):e22946
pubmed: 23526174
Int J Cancer. 2014 Sep 1;135(5):1178-86
pubmed: 24501019
FASEB J. 2005 Dec;19(14):2005-7
pubmed: 16223785
Br J Cancer. 2004 Oct 4;91(7):1316-26
pubmed: 15365564
Am J Pathol. 2020 Jan;190(1):222-233
pubmed: 31654638
PLoS One. 2011 Mar 31;6(3):e18219
pubmed: 21483813
Biosci Trends. 2020 Jan 20;13(6):469-475
pubmed: 31866615
Trends Immunol. 2019 Jul;40(7):648-664
pubmed: 31155315
Cell. 2015 Dec 17;163(7):1663-77
pubmed: 26627738
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20262-7
pubmed: 18077379
Front Cell Dev Biol. 2020 Jan 31;8:23
pubmed: 32083078
J Exp Med. 2018 Nov 5;215(11):2778-2795
pubmed: 30282719
J Exp Clin Cancer Res. 2019 Jan 7;38(1):6
pubmed: 30616627
PLoS One. 2012;7(12):e51848
pubmed: 23272179
Int J Cancer. 2017 May 15;140(10):2321-2330
pubmed: 28177522
Oncotarget. 2018 Nov 23;9(92):36457-36473
pubmed: 30559930
Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12952
pubmed: 29772063
Mol Cells. 2014 Mar;37(3):189-95
pubmed: 24608805
J Clin Invest. 2020 Jan 2;130(1):389-403
pubmed: 31600172
J Cell Biol. 1997 Feb 10;136(3):707-16
pubmed: 9024699
Breast Cancer Res. 2015 Mar 27;17:45
pubmed: 25882816
Clin Exp Metastasis. 2018 Apr;35(4):255-267
pubmed: 29968171
Nature. 2015 Jun 18;522(7556):345-348
pubmed: 25822788
Front Oncol. 2020 Feb 07;10:109
pubmed: 32117758
Immunity. 2018 Feb 20;48(2):364-379.e8
pubmed: 29466759
Crit Rev Oncol Hematol. 2013 Oct;88(1):218-30
pubmed: 23602134
Blood. 1997 Nov 15;90(10):4153-61
pubmed: 9354686
Front Oncol. 2020 Feb 25;10:188
pubmed: 32161718
J Leukoc Biol. 2020 May;107(5):809-818
pubmed: 32170882
Nature. 2015 Dec 17;528(7582):413-7
pubmed: 26649828
Gastroenterology. 2016 Jun;150(7):1646-1658.e17
pubmed: 26924089
Biol Cell. 2017 Nov;109(11):375-380
pubmed: 28799166
Blood. 1975 Dec;46(6):913-9
pubmed: 173439
Nature. 2007 Dec 6;450(7171):825-31
pubmed: 18064003
Cell Mol Gastroenterol Hepatol. 2018 May 24;6(3):257-276
pubmed: 30109253
Cancer Cell. 2009 Sep 8;16(3):183-94
pubmed: 19732719
Immunity. 2020 May 19;52(5):856-871.e8
pubmed: 32289253
Am J Pathol. 2011 Sep;179(3):1455-70
pubmed: 21741942
J Exp Clin Cancer Res. 2015 Nov 18;34:141
pubmed: 26581194
Trends Cancer. 2017 Feb;3(2):149-160
pubmed: 28718445
Exp Cell Res. 2007 Feb 1;313(3):551-9
pubmed: 17141217
J Immunol. 2016 Nov 1;197(9):3725-3734
pubmed: 27707998
J Immunol. 2018 Sep 1;201(5):1389-1399
pubmed: 30021768
J Clin Invest. 2010 Apr;120(4):1151-64
pubmed: 20237412
Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12949
pubmed: 29734477
Nat Rev Immunol. 2018 May;18(5):309-324
pubmed: 29379212
Immunity. 2019 Jul 16;51(1):27-41
pubmed: 31315034
Cancer Cell. 2017 Sep 11;32(3):282-293
pubmed: 28898694
Cancer Res. 2012 Aug 15;72(16):3919-27
pubmed: 22751466
Oncoimmunology. 2016 Sep 27;5(10):e1219828
pubmed: 27853643
Cancer Cell. 2011 Sep 13;20(3):300-14
pubmed: 21907922
Int J Cancer. 2014 Mar 15;134(6):1346-58
pubmed: 24154944
J Clin Invest. 2013 Jul 1;:
pubmed: 23863628
Nat Cell Biol. 2018 Jul;20(7):836-846
pubmed: 29915358
Clin Cancer Res. 2008 Nov 1;14(21):6735-41
pubmed: 18980965
Blood. 2017 Apr 6;129(14):1991-2001
pubmed: 28143882
Oncogenesis. 2019 Jan 18;8(2):8
pubmed: 30659170
Nat Commun. 2016 Jul 06;7:12150
pubmed: 27381735
Trends Immunol. 2016 May;37(5):273-286
pubmed: 27055913
Blood. 2013 Mar 7;121(10):1677-89
pubmed: 23305731
Nat Cell Biol. 2016 Apr;18(4):356-65
pubmed: 27027486
Oncoimmunology. 2017 Sep 21;7(1):e1373234
pubmed: 29296528
Cancer Res. 2010 Jul 15;70(14):5649-69
pubmed: 20610625
J Immunol. 1987 Dec 1;139(11):3783-91
pubmed: 2824615
Sci Immunol. 2016 Aug;1(2):
pubmed: 28417112
Clin Cancer Res. 2017 Feb 1;23(3):833-844
pubmed: 27492974
J Immunol. 1992 Jul 1;149(1):113-9
pubmed: 1376745
Oncoimmunology. 2017 Jan 9;6(2):e1258504
pubmed: 28344866
Trends Immunol. 2019 Mar;40(3):228-242
pubmed: 30777721
Cancer Cell. 2017 Mar 13;31(3):355-367
pubmed: 28238683
Immunol Rev. 2016 Sep;273(1):11-28
pubmed: 27558325
Mutagenesis. 2010 Mar;25(2):149-54
pubmed: 19892774
Cancer Res. 2004 Aug 15;64(16):5839-49
pubmed: 15313928
Nat Rev Cancer. 2017 May;17(5):302-317
pubmed: 28303905
Cell Rep. 2019 Jun 25;27(13):3902-3915.e6
pubmed: 31242422
Oncotarget. 2017 Jun 28;8(53):90969-90978
pubmed: 29207617
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11060-11065
pubmed: 30301793
Hepatology. 2017 Jun;65(6):1920-1935
pubmed: 28133764
Int J Cancer. 1996 May 3;66(3):367-73
pubmed: 8621259
Leukemia. 1990 Sep;4(9):657-63
pubmed: 2395385
Mol Cancer. 2013 Dec 09;12(1):154
pubmed: 24321240
J Leukoc Biol. 2006 Feb;79(2):303-11
pubmed: 16330528
J Leukoc Biol. 2020 Mar 23;:
pubmed: 32202340
Semin Cancer Biol. 2013 Jun;23(3):159-70
pubmed: 23410636
Blood. 2010 Jul 29;116(4):625-7
pubmed: 20410504
Cancer Res. 2005 Oct 1;65(19):8896-904
pubmed: 16204061