Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy.
immunotherapy
lymphocytes
molecular imaging
onco-immunology
tumor microenvironment
Journal
Journal of experimental & clinical cancer research : CR
ISSN: 1756-9966
Titre abrégé: J Exp Clin Cancer Res
Pays: England
ID NLM: 8308647
Informations de publication
Date de publication:
18 May 2020
18 May 2020
Historique:
received:
13
02
2020
accepted:
28
04
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
3
2
2021
Statut:
epublish
Résumé
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive tumor progression, metastatization and resistance to therapy. New immunotherapeutic approaches aim at restoring the natural balance and increase immune response against cancer by different mechanisms. The complexity of these interactions and the heterogeneity of immune cell subpopulations are a real challenge when trying to develop new immunotherapeutics and evaluate or predict their efficacy in vivo. To this purpose, molecular imaging can offer non-invasive diagnostic tools like radiopharmaceuticals, contrast agents or fluorescent dyes. These agents can be useful for preclinical and clinical purposes and can overcome [
Identifiants
pubmed: 32423420
doi: 10.1186/s13046-020-01586-y
pii: 10.1186/s13046-020-01586-y
pmc: PMC7236372
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
89Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 20411
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