Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
10
10
2019
accepted:
23
04
2020
revised:
01
04
2020
pubmed:
20
5
2020
medline:
1
2
2022
entrez:
20
5
2020
Statut:
ppublish
Résumé
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.
Identifiants
pubmed: 32424236
doi: 10.1038/s41380-020-0754-0
pii: 10.1038/s41380-020-0754-0
pmc: PMC8589647
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5124-5139Subventions
Organisme : NIA NIH HHS
ID : RF1 AG041915
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH083968
Pays : United States
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : CIHR
ID : 142255
Pays : Canada
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG058507
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD050735
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH113871
Pays : United States
Organisme : NIA NIH HHS
ID : T35 AG026757
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH090421
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCCIH NIH HHS
ID : R61 AT009864
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121312
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH101495
Pays : United States
Organisme : NCRR NIH HHS
ID : P41 RR008079
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH073526
Pays : United States
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001872
Pays : United States
Organisme : CIHR
ID : 106469
Pays : Canada
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : Medical Research Council
ID : MR/R024790/2
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : K01 MH117442
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085734
Pays : United States
Organisme : NCCIH NIH HHS
ID : R21 AT009173
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051710
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059874
Pays : United States
Informations de copyright
© 2020. The Author(s).
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