Effects of walnut oil on metabolic profile and transcription factors in rats fed high-carbohydrate-/-fat diets.
antioxidant; high carbohydrate
high-fat diet
oxidative stress
walnut oil
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
16
11
2019
revised:
02
03
2020
accepted:
25
03
2020
pubmed:
20
5
2020
medline:
22
6
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
The aim of this study was to examine the effects of walnut oil (WO) on metabolic profile and transcription factors in rats fed high carbohydrate (HCD) and high-fat diet (HFD). Forty-two male rats were divided in to six groups: (a) Control, (b) WO (20 mg/kg BW), (c) HCD (20% of sucrose), (d) HCD + WO (e) HFD (42% of calories as fat), and (f) HFD + WO. HFD and HCD intake increased final body weights by 19% and 23% and visceral fat weights by 3- and 5-fold, respectively (p < .05 for all). In addition, serum glucose, total cholesterol, triglyceride, and free fatty acids (FFA) insulin, leptin, and MDA levels increased in rats fed with HFD and HCD. WO supplementation improved these metabolic parameters (p < .05 for all). HFD + WO and HCD + WO treated groups had a significant reduction in serum and liver malondialdehyde (MDA) levels by 12% or 15% (p < .05 for both). In addition, WO supplementation lowered the levels of hepatic nuclear factor kappa B (NF-κB) and NADPH oxidase subunit p22
Substances chimiques
Carbohydrates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13235Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
Adelakun, S. A., Ukwenya, V. O., Ogunlade, B. S., Aniah, J. A., & Ibiayo, A. G. (2019). Nitrite-induced testicular toxicity in rats: Therapeutic potential of walnut oil. JBRA Assisted Reproduction, 23(1), 15-23. https://doi.org/10.5935/1518-0557.20180062
Amin, K. A., Kamel, H. H., & Abd Eltawab, M. A. (2011). Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Lipids in Health and Disease, 10, 6. https://doi.org/10.1186/1476-511X-10-6
Anderson, E. J., Thayne, K., Harris, M., Carraway, K., & Shaikh, S. R. (2012). Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids. The Biochemical Journal, 441(1), 359-366. https://doi.org/10.1042/BJ20110626
Atanasov, A. G., Waltenberger, B., Pferschy-Wenzig, E.-M., Linder, T., Wawrosch, C., Uhrin, P., … Stuppner, H. (2015). Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances, 33(8), 1582-1614. https://doi.org/10.1016/j.biotechadv.2015.08.001
Batirel, S., Yilmaz, A. M., Sahin, A., Perakakis, N., Kartal Ozer, N., & Mantzoros, C. S. (2018). Antitumor and antimetastatic effects of walnut oil in esophageal adenocarcinoma cells. Clinical Nutrition (Edinburgh, Scotland), 37(6), 2166-2171, https://doi.org/10.1016/j.clnu.2017.10.016
Bostani, M., Aqababa, H., Hosseini, S. E., & Ashtiyani, S. C. (2014). A study on the effects of walnut oil on plasma levels of testosterone pre and post puberty in male rats. American Journal of Ethnomedicine, 1(4).
Chan, R. S. M., & Woo, J. (2010). Prevention of overweight and obesity: How effective is the current public health approach. International Journal of Environmental Research and Public Health, 7(3), 765-783. https://doi.org/10.3390/ijerph7030765
Choi, Y., Abdelmegeed, M. A., Akbar, M., & Song, B.-J. (2016). Dietary walnut reduces hepatic triglyceride content in high-fat-fed mice via modulation of hepatic fatty acid metabolism and adipose tissue inflammation. The Journal of Nutritional Biochemistry, 30, 116-125. https://doi.org/10.1016/j.jnutbio.2015.12.005
Choi, Y., Abdelmegeed, M. A., & Song, B.-J. (2016). Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice. The Journal of Nutritional Biochemistry, 38, 70-80. https://doi.org/10.1016/j.jnutbio.2016.08.013
Chung, A. P. Y. S., Gurtu, S., Chakravarthi, S., Moorthy, M., & Palanisamy, U. D. (2018). Geraniin protects high-fat diet-induced oxidative stress in Sprague Dawley rats. Frontiers in Nutrition, 5, https://doi.org/10.3389/fnut.2018.00017
Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates, Publishers.
Dasilva, G., Pazos, M., García-Egido, E., Gallardo, J. M., Ramos-Romero, S., Torres, J. L., … Medina, I. (2017). A lipidomic study on the regulation of inflammation and oxidative stress targeted by marine ω-3 PUFA and polyphenols in high-fat high-sucrose diets. The Journal of Nutritional Biochemistry, 43, 53-67. https://doi.org/10.1016/j.jnutbio.2017.02.007
Delaviz, H., Mohammadi, J., Ghalamfarsa, G., Mohammadi, B., & Farhadi, N. (2017). A review study on phytochemistry and pharmacology applications of juglans regia plant. Pharmacognosy Reviews, 11(22), 145-152. https://doi.org/10.4103/phrev.phrev_10_17
Eguchi, A., & Feldstein, A. E. (2014). Adipocyte cell death, fatty liver disease and associated metabolic disorders. Digestive Diseases (Basel, Switzerland), 32(5), 579-585. https://doi.org/10.1159/000360509
Eidi, A., Moghadam, J. Z., Mortazavi, P., Rezazadeh, S., & Olamafar, S. (2013). Hepatoprotective effects of Juglans regia extract against CCl4-induced oxidative damage in rats. Pharmaceutical Biology, 51(5), 558-565. https://doi.org/10.3109/13880209.2012.749920
Erel, O. (2004). A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical Biochemistry, 37(2), 112-119. https://doi.org/10.1016/j.clinbiochem.2003.10.014
Farías, J. G., Carrasco-Pozo, C., Carrasco Loza, R., Sepúlveda, N., Álvarez, P., Quezada, M., … Castillo, R. L. (2017). Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2. Experimental Biology and Medicine (Maywood, N.J.), 242(10), 1104-1114. https://doi.org/10.1177/1535370216649263
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175-191. https://doi.org/10.3758/BF03193146
Fernando, H. A., Chin, H.-F., Ton, S. H., & Abdul Kadir, K. (2013). Stress and its effects on glucose metabolism and 11β-HSD activities in rats fed on a combination of high-fat and high-sucrose diet with glycyrrhizic acid. Journal of Diabetes Research, 2013, 190395. https://doi.org/10.1155/2013/190395
Fink, A., Rüfer, C. E., Le Grandois, J., Roth, A., Aoude-Werner, D., Marchioni, E., … Barth, S. W. (2014). Dietary walnut oil modulates liver steatosis in the obese Zucker rat. European Journal of Nutrition, 53(2), 645-660. https://doi.org/10.1007/s00394-013-0573-z
Gencoglu, H., Tuzcu, M., Hayirli, A., & Sahin, K. (2015). Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters. International Journal of Food Sciences and Nutrition, 66(3), 314-320. https://doi.org/10.3109/09637486.2014.1003534
Gillum, M. P., Kotas, M. E., Erion, D. M., Kursawe, R., Chatterjee, P., Nead, K. T., … Shulman, G. I. (2011). SirT1 regulates adipose tissue inflammation. Diabetes, 60(12), 3235-3245. https://doi.org/10.2337/db11-0616
Hardman, W. E. (2014). Walnuts Have potential for cancer prevention and treatment in mice123. The Journal of Nutrition, 144(4), 555S-560S. https://doi.org/10.3945/jn.113.188466
Hardman, W. E., Ion, G., Akinsete, J. A., & Witte, T. R. (2011). Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse. Nutrition and Cancer, 63(6), 960-970. https://doi.org/10.1080/01635581.2011.589959
Hardman, W. E., Primerano, D. A., Legenza, M. T., Morgan, J., Fan, J., & Denvir, J. (2019). Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast Cancer patients: A pilot clinical trial. Nutrition Research, 66, 82-94. https://doi.org/10.1016/j.nutres.2019.03.004
Hemler, E. C., & Hu, F. B. (2019). Plant-based diets for cardiovascular disease prevention: All plant foods are not created equal. Current Atherosclerosis Reports, 21(5), 18. https://doi.org/10.1007/s11883-019-0779-5
Hwang, L.-L., Wang, C.-H., Li, T.-L., Chang, S.-D., Lin, L.-C., Chen, C.-P., … Chiou, L.-C. (2010). Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obesity (Silver Spring, Md.), 18(3), 463-469. https://doi.org/10.1038/oby.2009.273
Jayarathne, S., Koboziev, I., Park, O.-H., Oldewage-Theron, W., Shen, C.-L., & Moustaid-Moussa, N. (2017). Anti-inflammatory and anti-obesity properties of food bioactive components: Effects on adipose tissue. Preventive Nutrition and Food Science, 22(4), 251-262. https://doi.org/10.3746/pnf.2017.22.4.251
Kim, K. M., & Ki, S. H. (2017). Chapter 28-Nrf2: A key regulator of redox signaling in liver diseases. In P. Muriel (Ed.), Liver Pathophysiology (pp. 355-374). Cambridge, Massachusetts, USA: Academic Press. https://doi.org/10.1016/B978-0-12-804274-8.00028-X
KunduSen, S., Gupta, M., Mazumder, U. K., Haldar, P. K., Saha, P., Bhattacharya, S., … Bala, A. (2011). Antihyperglycemic effect and antioxidant property of citrus maxima leaf in streptozotocin- induced diabetic rats. Diabetologia Croatica, 40, 113-120.
Kyrou, I., Randeva, H. S., Tsigos, C., Kaltsas, G., & Weickert, M. O. (2000). Clinical problems caused by obesity. In K. R. Feingold, B. Anawalt, A. Boyce, G. Chrousos, K. Dungan, A. Grossman, … D. P. Wilson (Ed.), Endotext. http://www.ncbi.nlm.nih.gov/books/NBK278973/.
Le, V. Y., Esposito, D., Grace, M. H., Ha, D., Pham, A., Bortolazzo, A., … White, J. B. (2014). Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells. Nutrition and Cancer, 66(8), 1304-1314. https://doi.org/10.1080/01635581.2014.956246
Lean, M. E. J., Astrup, A., & Roberts, S. B. (2018). Making progress on the global crisis of obesity and weight management. BMJ, 361, k2538. https://doi.org/10.1136/bmj.k2538
Leon, B. M., & Maddox, T. M. (2015). Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World Journal of Diabetes, 6(13), 1246-1258. https://doi.org/10.4239/wjd.v6.i13.1246
Lescano de Souza Junior, A., Mancini Filho, J., Pavan Torres, R., Irigoyen, M. C., & Curi, R. (2017). Pretreatment with fish oil attenuates heart ischaemia consequences in rats. Experimental Physiology, 102(11), 1459-1473. https://doi.org/10.1113/EP086332
Liu, H., Zhong, H., Yin, Y., & Jiang, Z. (2017). Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 91, 964-969. https://doi.org/10.1016/j.biopha.2017.04.130
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017). NF-κB signaling in inflammation. Signal Transduction and Targeted Therapy, 2, 17023. https://doi.org/10.1038/sigtrans.2017.23
Liu, X., Zhao, H., Luo, C., Du, D., Huang, J., Ming, Q., … Huang, W. (2019). Acetaminophen responsive miR-19b modulates SIRT1/Nrf2 signaling pathway in drug-induced hepatotoxicity. Toxicological Sciences: An Official Journal of the Society of Toxicology, 170(2), 476-488. https://doi.org/10.1093/toxsci/kfz095
Luo, T., Miranda-Garcia, O., Adamson, A., Hamilton-Reeves, J., Sullivan, D. K., Kinchen, J. M., & Shay, N. F. (2016). Consumption of walnuts in combination with other whole foods produces physiologic, metabolic, and gene expression changes in obese C57BL/6J high-fat-fed male mice. The Journal of Nutrition, 146(9), 1641-1650. https://doi.org/10.3945/jn.116.234419
Manea, A., Manea, S. A., Gafencu, A. V., & Raicu, M. (2007). Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells. Archives of Physiology and Biochemistry, 113(4-5), 163-172. https://doi.org/10.1080/13813450701531235
Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh, D. Y., Izquierdo, C. L., … Olefsky, J. M. (2015). Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Molecular Metabolism, 4(5), 378-391. https://doi.org/10.1016/j.molmet.2015.02.007
Mendez-Sanchez, N., Cruz-Ramon, V. C., Ramirez-Perez, O. L., Hwang, J. P., Barranco-Fragoso, B., & Cordova-Gallardo, J. (2018). New aspects of lipotoxicity in nonalcoholic steatohepatitis. International Journal of Molecular Sciences, 19(7), 2034-https://doi.org/10.3390/ijms19072034
Milton-Laskibar, I., Aguirre, L., Fernández-Quintela, A., Rolo, A. P., Soeiro Teodoro, J., Palmeira, C. M., & Portillo, M. P. (2017). Lack of additive effects of resveratrol and energy restriction in the treatment of hepatic steatosis in rats. Nutrients, 9(7), 737. https://doi.org/10.3390/nu9070737
Molinar-Toribio, E., Fuguet, E., Ramos-Romero, S., Taltavull, N., Méndez, L., Nogués, M. R., … Pérez-Jiménez, J. (2018). A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats. European Journal of Nutrition, 57(1), 339-349. https://doi.org/10.1007/s00394-016-1323-9
Moravej, H., Salehi, A., Razavi, Z., Moein, M. R., Etemadfard, H., Karami, F., & Ghahremani, F. (2016). Chemical composition and the effect of walnut hydrosol on glycemic control of patients with type 1 diabetes. International Journal of Endocrinology and Metabolism, 14(1), e34726. https://doi.org/10.5812/ijem.34726
Mota, M., Banini, B. A., Cazanave, S. C., & Sanyal, A. J. (2016). Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. Metabolism: Clinical and Experimental, 65(8), 1049-1061. https://doi.org/10.1016/j.metabol.2016.02.014
National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. (2011). Guide for the care and use of laboratory animals (8th bs). http://www.ncbi.nlm.nih.gov/books/NBK54050/
Oliveira, I., Sousa, A., Ferreira, I. C. F. R., Bento, A., Estevinho, L., & Pereira, J. A. (2008). Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 46(7), 2326-2331. https://doi.org/10.1016/j.fct.2008.03.017
Pan, A., Sun, Q., Manson, J. E., Willett, W. C., & Hu, F. B. (2013). Walnut consumption is associated with lower risk of type 2 diabetes in women. The Journal of Nutrition, 143(4), 512-518. https://doi.org/10.3945/jn.112.172171
Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015). NADPH oxidases: An overview from structure to innate immunity-associated pathologies. Cellular and Molecular Immunology, 12(1), 5-23. https://doi.org/10.1038/cmi.2014.89
Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., & Tschöp, M. H. (2008). Sirt1 protects against high-fat diet-induced metabolic damage. Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9793-9798. https://doi.org/10.1073/pnas.0802917105
Pi-Sunyer, X. (2009). The medical risks of obesity. Postgraduate Medicine, 121(6), 21-33. https://doi.org/10.3810/pgm.2009.11.2074
Qiu, Y., Tao, L., Lei, C., Wang, J., Yang, P., Li, Q., & Lei, B. (2015). Downregulating p22phox ameliorates inflammatory response in Angiotensin II-induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells. Scientific Reports, 5(1), 1-14. https://doi.org/10.1038/srep14362
Rahimi, P. (2011). Anti-diabetic effects of walnut oil on alloxan-induced diabetic rats. African Journal of Pharmacy and Pharmacology, 5(24), https://doi.org/10.5897/AJPP11.480
Rodgers, J. T., & Puigserver, P. (2007). Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proceedings of the National Academy of Sciences of the United States of America, 104(31), 12861-12866. https://doi.org/10.1073/pnas.0702509104
Ros, E. (2010). Health benefits of nut consumption. Nutrients, 2(7), 652-682. https://doi.org/10.3390/nu2070652
Sahin, K., Orhan, C., Akdemir, F., Tuzcu, M., Sahin, N., Yılmaz, I., & Juturu, V. (2017). β-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-κB and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 107(Pt A), 270-279. https://doi.org/10.1016/j.fct.2017.07.008
Sahin, K., Orhan, C., Tuzcu, M., Sahin, N., Ozdemir, O., & Juturu, V. (2017). Ingested capsaicinoids can prevent -high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways. Journal of Inflammation Research, 10, 161-168. https://doi.org/10.2147/JIR.S149087
Sahin, K., Tuzcu, M., Orhan, C., Sahin, N., Kucuk, O., Ozercan, I. H., … Komorowski, J. R. (2013). Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin. The British Journal of Nutrition, 110(2), 197-205. https://doi.org/10.1017/S0007114512004850
Sánchez-González, C., Ciudad, C. J., Noé, V., & Izquierdo-Pulido, M. (2017). Health benefits of walnut polyphenols: An exploration beyond their lipid profile. Critical Reviews in Food Science and Nutrition, 57(16), 3373-3383. https://doi.org/10.1080/10408398.2015.1126218
Seki, S., Kitada, T., Yamada, T., Sakaguchi, H., Nakatani, K., & Wakasa, K. (2002). In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. Journal of Hepatology, 37(1), 56-62. https://doi.org/10.1016/S0168-8278(02)00073-9
Sengupta, P. (2013). The laboratory rat: Relating its age with human’s. International Journal of Preventive Medicine, 4(6), 624-630. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733029/
Showalter, M. R., Nonnecke, E. B., Linderholm, A. L., Cajka, T., Sa, M. R., Lönnerdal, B. O., … Fiehn, O. (2018). Obesogenic diets alter metabolism in mice. PLoS ONE, 13(1), e0190632. https://doi.org/10.1371/journal.pone.0190632
Smith, R. E., Tran, K., Smith, C. C., McDonald, M., Shejwalkar, P., & Hara, K. (2016). The role of the Nrf2/ARE antioxidant system in preventing cardiovascular diseases. Diseases, 4(4), https://doi.org/10.3390/diseases4040034
Soussi, A., Gargouri, M., & El Feki, A. (2018). Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead-mediated hepatic damage and their interaction with lipase activity in rats. Environmental Toxicology, 33(12), 1261-1271. https://doi.org/10.1002/tox.22634
Stern, J. H., Rutkowski, J. M., & Scherer, P. E. (2016). Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metabolism, 23(5), 770-784. https://doi.org/10.1016/j.cmet.2016.04.011
Storz, M. A. (2018). Is there a lack of support for whole-food, plant-based diets in the medical community? The Permanente Journal, 23, https://doi.org/10.7812/TPP/18-068
Takahashi, A., Okazaki, Y., Nakamoto, A., Watanabe, S., Sakaguchi, H., Tagashira, Y., … Chiji, H. (2014). Dietary anthocyanin-rich Haskap phytochemicals inhibit postprandial hyperlipidemia and hyperglycemia in rats. Journal of Oleo Science, 63(3), 201-209. https://doi.org/10.5650/jos.ess13196
Torres-Villalobos, G., Hamdan-Pérez, N., Tovar, A. R., Ordaz-Nava, G., Martínez-Benítez, B., Torre-Villalvazo, I., … Torres, N. (2015). Combined high-fat diet and sustained high sucrose consumption promotes NAFLD in a murine model. Annals of Hepatology, 14(4), 540-546. https://doi.org/10.1016/S1665-2681(19)31176-7
Tsai, I.-J., Chen, C.-W., Tsai, S.-Y., Wang, P.-Y., Owaga, E., & Hsieh, R.-H. (2018). Curcumin supplementation ameliorated vascular dysfunction and improved antioxidant status in rats fed a high-sucrose, high-fat diet. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 43(7), 669-676. https://doi.org/10.1139/apnm-2017-0670
Tuzcu, Z., Orhan, C., Sahin, N., Juturu, V., & Sahin, K. (2017). Cinnamon polyphenol extract inhibits hyperlipidemia and inflammation by modulation of transcription factors in high-fat diet-fed rats. Oxidative Medicine and Cellular Longevity, 2017, 1583098. https://doi.org/10.1155/2017/1583098
Xia, L., Tan, S., Zhou, Y., Lin, J., Wang, H., Oyang, L., … Liao, Q. (2018). Role of the NFκB-signaling pathway in cancer. OncoTargets and Therapy, 11, 2063-2073. https://doi.org/10.2147/OTT.S161109
Yamamoto, Y., & Oue, E. (2006). Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet. Bioscience, Biotechnology, and Biochemistry, 70(4), 933-939. https://doi.org/10.1271/bbb.70.933
Zanetti, M., Gortan Cappellari, G., Barbetta, D., Semolic, A., & Barazzoni, R. (2017). Omega 3 polyunsaturated fatty acids improve endothelial dysfunction in chronic renal failure: Role of eNOS activation and of oxidative stress. Nutrients, 9(8), https://doi.org/10.3390/nu9080895
Zeng, X., Zhu, M., Liu, X., Chen, X., Yuan, Y., Li, L., … Chen, Y. (2020). Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis. Nutrition & Metabolism, 17, 11. https://doi.org/10.1186/s12986-020-0434-8
Zibaeenezhad, M., Aghasadeghi, K., Hakimi, H., Yarmohammadi, H., & Nikaein, F. (2016). The effect of walnut oil consumption on blood sugar in patients with diabetes mellitus type 2. International Journal of Endocrinology and Metabolism, 14(3), https://doi.org/10.5812/ijem.34889
Zibaeenezhad, M. J., Farhadi, P., Attar, A., Mosleh, A., Amirmoezi, F., & Azimi, A. (2017). Effects of walnut oil on lipid profiles in hyperlipidemic type 2 diabetic patients: A randomized, double-blind, placebo-controlled trial. Nutrition & Diabetes, 7(4), e259. https://doi.org/10.1038/nutd.2017.8