A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model.

Amniotic Fluid / microbiology Animals Animals, Newborn Cesarean Section Chemokines / antagonists & inhibitors Cytokines / analysis Female Macrophages / physiology Morbidity Neutrophils / drug effects Obstetric Labor, Premature / prevention & control Pregnancy Primates Streptococcal Infections / complications Streptococcus agalactiae / pathogenicity
chemokine chorioamniotic membranes fetus group B streptoccocus infection neutrophil placenta preterm labor

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 31 01 2020
accepted: 06 04 2020
entrez: 20 5 2020
pubmed: 20 5 2020
medline: 27 3 2021
Statut: epublish

Résumé

Leukocyte activation within the chorioamniotic membranes is strongly associated with inflammation and preterm labor (PTL). We hypothesized that prophylaxis with a broad-spectrum chemokine inhibitor (BSCI) would downregulate the inflammatory microenvironment induced by Group B Streptococcus (GBS,

Identifiants

DOI: 10.3389/fimmu.2020.00770 PMID: 32425945 PMC: PMC7203489
pubmed: 32425945
doi: 10.3389/fimmu.2020.00770
pmc: PMC7203489
doi:

Substances chimiques

Chemokines 0
Cytokines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

770

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NIH HHS
ID : P51 OD010425
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133976
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145890
Pays : United States

Informations de copyright

Copyright © 2020 Coleman, Orvis, Wu, Dacanay, Merillat, Ogle, Baldessari, Kretzer, Munson, Boros-Rausch, Shynlova, Lye, Rajagopal and Adams Waldorf.

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Auteurs

Michelle Coleman (M)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.

Austyn Orvis (A)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.

Tsung-Yen Wu (TY)

Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, United States.

Matthew Dacanay (M)

Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, United States.

Sean Merillat (S)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.

Jason Ogle (J)

Washington National Primate Center, University of Washington, Seattle, WA, United States.

Audrey Baldessari (A)

Washington National Primate Center, University of Washington, Seattle, WA, United States.

Nicole M Kretzer (NM)

Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, United States.

Jeff Munson (J)

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States.

Adam J Boros-Rausch (AJ)

Department of Physiology, University of Toronto, Toronto, ON, Canada.

Oksana Shynlova (O)

Department of Physiology, University of Toronto, Toronto, ON, Canada.
Department of Obstetrics & Gynaecology, University of Toronto, Toronto, ON, Canada.

Stephen Lye (S)

Department of Physiology, University of Toronto, Toronto, ON, Canada.
Department of Obstetrics & Gynaecology, University of Toronto, Toronto, ON, Canada.

Lakshmi Rajagopal (L)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Department of Pediatrics, University of Washington, Seattle, WA, United States.
Department of Global Health, University of Washington, Seattle, WA, United States.

Kristina M Adams Waldorf (KM)

Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, United States.
Department of Global Health, University of Washington, Seattle, WA, United States.

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Classifications MeSH

questionsmedicales.fr › Structures de l'embryon › Foetus › Liquide amniotique › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Eucaryotes › Animaux › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie obstétrique › Accouchement (procédure) › Césarienne › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications du travail obstétrical › Travail obstétrical prématuré › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à streptocoques › A Broad Spectrum Chemokine Inhibitor Prevents...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus agalactiae › A Broad Spectrum Chemokine Inhibitor Prevents...