Targeted metabolomic analysis of serum phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle.
Fontan
acylcarnitine
angiogenesis
congenital heart disease
heart failure
inflammation
lipid
lymphatic vessel
metabolism
metabolomics
phosphatidylcholine
phospholipid
sphingomyelin
vascular stiffening
Journal
Therapeutic advances in chronic disease
ISSN: 2040-6223
Titre abrégé: Ther Adv Chronic Dis
Pays: United States
ID NLM: 101532140
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
06
2019
accepted:
19
02
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
20
5
2020
Statut:
epublish
Résumé
Patients with a Fontan circulation have altered cholesterol and lipoprotein values. We analysed small organic molecules in extended phopsholipid and acylcarnitine metabolic pathways ('metabolomes') in adult Fontan patients with a dominant left ventricle, seeking differences between profiles in baseline and Fontan circulations. In an observational matched cross-sectional study, we compared phosphatidylcholine (PC), sphingomyelin (SM), and acylcarnitine metabolomes (105 analytes; AbsoluteIDQ Serum levels of total PC ( Metabolomic profiling can use small specimens to identify biomarker patterns that track derangement in multiple metabolic pathways. The striking alterations in the phospholipid and acylcarnitine metabolome that we found in Fontan patients may reflect altered cell signalling and metabolism as found in heart failure in biventricular patients, chronic low-level inflammation, and alteration of functional or structural properties of lymphatic or blood vessels. ClinicalTrials.gov Identifier NCT03886935.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with a Fontan circulation have altered cholesterol and lipoprotein values. We analysed small organic molecules in extended phopsholipid and acylcarnitine metabolic pathways ('metabolomes') in adult Fontan patients with a dominant left ventricle, seeking differences between profiles in baseline and Fontan circulations.
METHODS
METHODS
In an observational matched cross-sectional study, we compared phosphatidylcholine (PC), sphingomyelin (SM), and acylcarnitine metabolomes (105 analytes; AbsoluteIDQ
RESULTS
RESULTS
Serum levels of total PC (
CONCLUSION
CONCLUSIONS
Metabolomic profiling can use small specimens to identify biomarker patterns that track derangement in multiple metabolic pathways. The striking alterations in the phospholipid and acylcarnitine metabolome that we found in Fontan patients may reflect altered cell signalling and metabolism as found in heart failure in biventricular patients, chronic low-level inflammation, and alteration of functional or structural properties of lymphatic or blood vessels.
TRIAL REGISTRATION NUMBER
BACKGROUND
ClinicalTrials.gov Identifier NCT03886935.
Identifiants
pubmed: 32426103
doi: 10.1177/2040622320916031
pii: 10.1177_2040622320916031
pmc: PMC7222265
doi:
Banques de données
ClinicalTrials.gov
['NCT03886935']
Types de publication
Journal Article
Langues
eng
Pagination
2040622320916031Informations de copyright
© The Author(s), 2020.
Déclaration de conflit d'intérêts
Conflict of interest statement: MM, KOD, MZ, DK, MGA, AE, MK, JK, IOK, RG, CS, CN, UM, SS-B, and KTL declare that they have no financial or non-financial competing interests with respect to the research, authorship, and/or publication of this article.
Références
Pediatr Cardiol. 2012 Oct;33(7):1154-9
pubmed: 22411716
Int J Cardiol. 2007 Jan 18;114(3):345-51
pubmed: 16777247
Rev Endocr Metab Disord. 2018 Mar;19(1):93-106
pubmed: 29926323
Eur J Cardiothorac Surg. 2009 Dec;36(6):980-5
pubmed: 19643621
J Am Heart Assoc. 2016 Jan 11;5(1):
pubmed: 26755550
Ann Thorac Surg. 2014 Apr;97(4):1394-9
pubmed: 24424012
J Pediatr. 2016 Apr;171:73-7
pubmed: 26806364
Cardiol Young. 2016 Jun;26(5):876-84
pubmed: 26279316
Ann Chir Thorac Cardiovasc. 1971 Jan;10(1):39-47
pubmed: 5101717
Circulation. 2016 Feb 23;133(8):706-16
pubmed: 26819374
Circ Cardiovasc Imaging. 2019 Apr;12(4):e008972
pubmed: 30943768
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):e1-e11
pubmed: 28122777
Biochem Soc Trans. 2017 Oct 15;45(5):1105-1115
pubmed: 28900017
Cell Chem Biol. 2017 Dec 21;24(12):1445-1454.e8
pubmed: 29033315
J Pharm Biomed Anal. 2016 Sep 10;129:34-42
pubmed: 27394176
Cardiol Young. 2013 Dec;23(6):831-40
pubmed: 24401255
Circulation. 2005 Aug 9;112(6):828-35
pubmed: 16061735
Curr Med Chem. 2007;14(30):3209-20
pubmed: 18220755
N Engl J Med. 2007 Mar 15;356(11):1140-51
pubmed: 17360992
Int J Cardiol. 2019 Jan 1;274:80-87
pubmed: 30029798
Int J Cardiol. 2015 Apr 1;184:623-630
pubmed: 25771227
Chem Phys Lipids. 2016 May;197:45-59
pubmed: 26200918
J Lipid Res. 2000 Jul;41(7):1035-47
pubmed: 10884283
J Am Coll Cardiol. 2012 Nov 20;60(21):2140-9
pubmed: 23021324
Cardiovasc Ultrasound. 2014 Apr 10;12:15
pubmed: 24716671
Heart. 2018 Mar;104(5):394-400
pubmed: 28942393
Can J Cardiol. 2019 Feb;35(2):217-220
pubmed: 30760429
J Lipid Res. 2005 Jun;46(6):1213-28
pubmed: 15741650
Cardiol Young. 2008 Dec;18(6):615-23
pubmed: 18838025
Free Radic Biol Med. 2017 Oct;111:6-24
pubmed: 28027924
Int J Cardiol. 2018 May 15;259:71-75
pubmed: 29472024
J Lipid Res. 2010 Oct;51(10):3074-87
pubmed: 20660127
Anal Chem. 2017 Jan 3;89(1):656-665
pubmed: 27959516
Sci Rep. 2018 Apr 12;8(1):5894
pubmed: 29650978
Ann Thorac Surg. 2006 Aug;82(2):695-700
pubmed: 16863787
Am J Cardiol. 2005 Jul 15;96(2):283-90
pubmed: 16018858
J Mol Cell Cardiol. 2013 Jun;59:76-85
pubmed: 23454301
Heart. 2018 Feb;104(4):324-331
pubmed: 28970278
J Thorac Cardiovasc Surg. 2019 Feb;157(2):699-707
pubmed: 30396734
Ann Rheum Dis. 2009 Apr;68(4):460-9
pubmed: 19286905
Cardiol Young. 2017 Jan;27(1):59-68
pubmed: 28281411
J Lab Clin Med. 1989 Feb;113(2):235-40
pubmed: 2915187
J Am Heart Assoc. 2014 Aug 13;3(4):
pubmed: 25122663
Cardiovasc Hematol Disord Drug Targets. 2019;19(3):205-214
pubmed: 30747084
Int J Mol Sci. 2013 Apr 09;14(4):7716-41
pubmed: 23571495
J Pediatr. 2013 Jun;162(6):1199-204
pubmed: 23312682
Eur Heart J. 2018 Sep 7;39(34):3253-3261
pubmed: 30010900
IUBMB Life. 2010 Jun;62(6):414-28
pubmed: 20503434
N Engl J Med. 1990 Jul 26;323(4):236-41
pubmed: 2195340
Am J Cardiol. 2010 Mar 15;105(6):869-73
pubmed: 20211335
Expert Rev Cardiovasc Ther. 2008 Feb;6(2):165-74
pubmed: 18248271
Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1132-40
pubmed: 27055903
Circulation. 2017 Jan 17;135(3):264-279
pubmed: 27832613
Heart. 2019 Dec;105(23):1777-1784
pubmed: 31585946
Eur Heart J. 2006 Nov;27(21):2588-605
pubmed: 17000623
Int J Cardiol. 2017 Jan 15;227:691-697
pubmed: 27816303
Am Heart J. 2009 Jul;158(1):30-9
pubmed: 19540389
Arterioscler Thromb Vasc Biol. 2015 May;35(5):1284-91
pubmed: 25745056