Alpha-fetoprotein level to total tumor volume as a predictor of hepatocellular carcinoma recurrence after resection. A retrospective cohort study.
Alfa fetoprotein
Hepatocellular carcinoma
Liver resection
Total tumor volume
Journal
Annals of medicine and surgery (2012)
ISSN: 2049-0801
Titre abrégé: Ann Med Surg (Lond)
Pays: England
ID NLM: 101616869
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
18
03
2020
revised:
08
04
2020
accepted:
13
04
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
20
5
2020
Statut:
epublish
Résumé
Total tumor volume (TTV) and serum alfa fetoprotein (AFP) level are important risk factors linked with the high possibility of hepatocellular carcinoma (HCC) recurrence. The aim of the study was to evaluate the role of AFP/TTV ratio, as a prognostic marker, in the prediction of HCC recurrence after resection. Patients who underwent liver resection for HCC between 2010 and 2018 were retrospectively analyzed. Patients were divided into 2 groups; a group with AFP/TTV ≤2 and another group with AFP/TTV >2. Risk factors for HCC recurrence were recorded. A total of 286 HCC patients underwent liver resection (184 patients with AFP/TTV ≤ 2, and 102 patients with AFP/TTV > 2). There was a significant difference between the 2 groups in the preoperative total bilirubin level, serum AFP level, mean tumor diameter, TTV, operative blood loss, microvascular invasion and hospital stay (all AFP/TTV ratio is a feasible prognostic marker for prediction of HCC recurrence after resection so, it can help in providing an intensive postoperative surveillance program to high risk patients for early detection and management of any recurrence.
Sections du résumé
BACKGROUND
BACKGROUND
Total tumor volume (TTV) and serum alfa fetoprotein (AFP) level are important risk factors linked with the high possibility of hepatocellular carcinoma (HCC) recurrence. The aim of the study was to evaluate the role of AFP/TTV ratio, as a prognostic marker, in the prediction of HCC recurrence after resection.
METHODS
METHODS
Patients who underwent liver resection for HCC between 2010 and 2018 were retrospectively analyzed. Patients were divided into 2 groups; a group with AFP/TTV ≤2 and another group with AFP/TTV >2. Risk factors for HCC recurrence were recorded.
RESULTS
RESULTS
A total of 286 HCC patients underwent liver resection (184 patients with AFP/TTV ≤ 2, and 102 patients with AFP/TTV > 2). There was a significant difference between the 2 groups in the preoperative total bilirubin level, serum AFP level, mean tumor diameter, TTV, operative blood loss, microvascular invasion and hospital stay (all
CONCLUSION
CONCLUSIONS
AFP/TTV ratio is a feasible prognostic marker for prediction of HCC recurrence after resection so, it can help in providing an intensive postoperative surveillance program to high risk patients for early detection and management of any recurrence.
Identifiants
pubmed: 32426129
doi: 10.1016/j.amsu.2020.04.014
pii: S2049-0801(20)30057-1
pmc: PMC7225379
doi:
Types de publication
Journal Article
Langues
eng
Pagination
109-113Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
No conflicts of interest.
Références
Ann Surg. 2019 Apr 30;:
pubmed: 31058698
Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1705-9
pubmed: 19102374
J Hepatol. 2009 Nov;51(5):890-7
pubmed: 19747749
Surgery. 2018 May;163(5):1002-1007
pubmed: 29284589
Int J Surg. 2019 Dec;72:156-165
pubmed: 31704426
Indian J Surg. 2017 Aug;79(4):299-307
pubmed: 28827903
Transl Gastroenterol Hepatol. 2019 Jul 11;4:52
pubmed: 31463411
Tumour Biol. 2016 Jul;37(7):9301-10
pubmed: 26779628
Anticancer Res. 2019 Jun;39(6):3033-3038
pubmed: 31177145
World J Surg. 2013 Jun;37(6):1348-55
pubmed: 23467925
J Surg Oncol. 1997 Feb;64(2):143-6
pubmed: 9047252
Korean J Intern Med. 2013 Jul;28(4):428-38
pubmed: 23864801
Internist (Berl). 2020 Feb;61(2):147-157
pubmed: 32016491
Korean J Hepatol. 2010 Jun;16(2):168-75
pubmed: 20606501
J Hepatol. 2010 Jul;53(1):108-17
pubmed: 20451283
Liver Transpl. 2008 Aug;14(8):1107-15
pubmed: 18668667
J Gastrointest Surg. 2013 Apr;17(4):730-8
pubmed: 23188220
Ann Surg. 2009 Aug;250(2):187-96
pubmed: 19638912
JAMA Surg. 2019 Mar 1;154(3):209-217
pubmed: 30422241
Hepatology. 2015 Jul;62(1):158-65
pubmed: 25777590
Clin Gastroenterol Hepatol. 2004 Sep;2(9):820-4
pubmed: 15354283
HPB (Oxford). 2019 Oct 10;:
pubmed: 31607637