Genital abnormalities associated to lack of uterine adenogenesis or endometrial gland dysgenesis of female dromedary camels (
Adenogenesis
Camel
Metritis
Uterine aplasia
Uterine glands
Journal
Open veterinary journal
ISSN: 2218-6050
Titre abrégé: Open Vet J
Pays: Libya
ID NLM: 101653182
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
05
08
2019
accepted:
15
01
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
10
4
2021
Statut:
ppublish
Résumé
The developmental disruption of the müllerian duct and the endometrial dynamic can generate genital lesions that could contribute to infertility. This paper discusses two cases of genital conditions associated to endometrial gland pathologies in nulliparous female camels. Macroscopic examinations and histopathological description were performed on congenital and acquired genital abnormalities with endometrial gland anomalies. The first case is endometrial gland agenesis associated to unilateral uterine aplasia, and the second case is endometrial gland dysgenesis associated to metritis. The prevalence of each case is estimated to be 0.6%. The most specific microscopic features associated to the endometrial gland agenesis were the presence of endometrial stromal proliferation and homogenous hyalinization of the myometrium. The acute metritis was associated to endometrial-activated stroma with focal infiltration with inflammatory cells on the endometrium and myometrium and the spontaneous endometrial gland dysgenesis. This study reveals the importance of congenital abnormalities during the routine reproductive examination of peripubertal animals, as well as the association of histopathological complementary examination for the research functional and inflammatory anomalies of the uterus. Genetic screening of breeders would be very important in the search for genetic risk factors associated with these congenital pathologies, which can be disseminated by reproductive biotechnologies.
Sections du résumé
Background
The developmental disruption of the müllerian duct and the endometrial dynamic can generate genital lesions that could contribute to infertility.
Aim
This paper discusses two cases of genital conditions associated to endometrial gland pathologies in nulliparous female camels.
Methods
Macroscopic examinations and histopathological description were performed on congenital and acquired genital abnormalities with endometrial gland anomalies.
Results
The first case is endometrial gland agenesis associated to unilateral uterine aplasia, and the second case is endometrial gland dysgenesis associated to metritis. The prevalence of each case is estimated to be 0.6%. The most specific microscopic features associated to the endometrial gland agenesis were the presence of endometrial stromal proliferation and homogenous hyalinization of the myometrium. The acute metritis was associated to endometrial-activated stroma with focal infiltration with inflammatory cells on the endometrium and myometrium and the spontaneous endometrial gland dysgenesis.
Conclusion
This study reveals the importance of congenital abnormalities during the routine reproductive examination of peripubertal animals, as well as the association of histopathological complementary examination for the research functional and inflammatory anomalies of the uterus. Genetic screening of breeders would be very important in the search for genetic risk factors associated with these congenital pathologies, which can be disseminated by reproductive biotechnologies.
Identifiants
pubmed: 32426256
doi: 10.4314/ovj.v10i1.8
pii: OVJ-10-44
pmc: PMC7193880
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-52Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
Références
Biol Reprod. 2001 Nov;65(5):1311-23
pubmed: 11673245
Anim Reprod Sci. 2001 Sep 15;67(3-4):135-52
pubmed: 11530260
Theriogenology. 2015 Aug;84(3):452-6
pubmed: 25935372
Reprod Domest Anim. 2017 Feb;52(1):174-178
pubmed: 27862412
Reprod Domest Anim. 2008 Jun;43(3):382-384
pubmed: 18179630
Development. 1997 Dec;124(23):4781-91
pubmed: 9428414
J Reprod Fertil. 1999 Sep;117(1):143-52
pubmed: 10645255
J Genet Syndr Gene Ther. 2013;4:
pubmed: 25506511
Biol Reprod. 2001 Jun;64(6):1608-13
pubmed: 11369585
J Vet Diagn Invest. 2005 Sep;17(5):490-2
pubmed: 16312246
Br Vet J. 1991 May-Jun;147(3):290-2
pubmed: 1878773
Mol Hum Reprod. 2013 Sep;19(9):547-58
pubmed: 23619340
Int J Dev Biol. 2009;53(2-3):411-24
pubmed: 19412895
Oncogene. 2009 Jan 8;28(1):31-40
pubmed: 18806829
Annu Rev Anim Biosci. 2019 Feb 15;7:125-147
pubmed: 30183326
Arch Gynecol Obstet. 2007 Jul;276(1):91-3
pubmed: 17235604
JFMS Open Rep. 2017 Dec 11;3(2):2055116917743614
pubmed: 29270306
Fertil Steril. 2006 Mar;85(3):750.e1-750.e4
pubmed: 16500349
Fertil Steril. 1983 Jul;40(1):80-5
pubmed: 6862042
Anat Histol Embryol. 2018 Dec;47(6):544-550
pubmed: 30058209
Br Vet J. 1995 Jul-Aug;151(4):443-52
pubmed: 7552200
Development. 1998 Aug;125(16):3201-11
pubmed: 9671592
Biol Reprod. 2010 Sep;83(3):396-403
pubmed: 20484741
Anim Reprod Sci. 2017 Jun;181:30-40
pubmed: 28413155
J Am Vet Med Assoc. 2010 Sep 1;237(5):542-6
pubmed: 20807131
Int J Dev Biol. 2014;58(2-4):107-16
pubmed: 25023676
Biol Reprod. 2000 Feb;62(2):448-56
pubmed: 10642586
Fertil Steril. 1989 May;51(5):747-55
pubmed: 2651163
Fertil Steril. 1983 Jul;40(1):86-90
pubmed: 6862043
Surg Endosc. 2003 Jan;17(1):161
pubmed: 12399856
Reproduction. 2002 Aug;124(2):289-300
pubmed: 12141942
Acta Histochem. 2014 Oct;116(8):1225-30
pubmed: 25081941