Wireless smart contact lens for diabetic diagnosis and therapy.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
23
11
2019
accepted:
31
01
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
20
5
2020
Statut:
epublish
Résumé
A smart contact lens can be used as an excellent interface between the human body and an electronic device for wearable healthcare applications. Despite wide investigations of smart contact lenses for diagnostic applications, there has been no report on electrically controlled drug delivery in combination with real-time biometric analysis. Here, we developed smart contact lenses for both continuous glucose monitoring and treatment of diabetic retinopathy. The smart contact lens device, built on a biocompatible polymer, contains ultrathin, flexible electrical circuits and a microcontroller chip for real-time electrochemical biosensing, on-demand controlled drug delivery, wireless power management, and data communication. In diabetic rabbit models, we could measure tear glucose levels to be validated by the conventional invasive blood glucose tests and trigger drugs to be released from reservoirs for treating diabetic retinopathy. Together, we successfully demonstrated the feasibility of smart contact lenses for noninvasive and continuous diabetic diagnosis and diabetic retinopathy therapy.
Identifiants
pubmed: 32426469
doi: 10.1126/sciadv.aba3252
pii: aba3252
pmc: PMC7182412
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaba3252Subventions
Organisme : NEI NIH HHS
ID : K08 EY028176
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY026877
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Références
Adv Mater. 2010 Nov 24;22(44):4925-43
pubmed: 20818618
Drug Deliv. 2019 Dec;26(1):522-531
pubmed: 31090470
Nat Biotechnol. 2019 Apr;37(4):389-406
pubmed: 30804534
Biosens Bioelectron. 2011 Mar 15;26(7):3290-6
pubmed: 21257302
Sci Transl Med. 2012 Feb 22;4(122):122ra21
pubmed: 22344516
Sci Adv. 2018 Jan 24;4(1):eaap9841
pubmed: 29387797
Arch Ophthalmol. 2012 Dec;130(12):1534-9
pubmed: 22892888
Biomaterials. 2011 Apr;32(11):3115-23
pubmed: 21277020
Nat Nanotechnol. 2014 May;9(5):397-404
pubmed: 24681776
Nat Biomed Eng. 2019 Jan;3(1):27-36
pubmed: 30932063
Nat Commun. 2017 Apr 27;8:14997
pubmed: 28447604
Nature. 2016 Jan 28;529(7587):509-514
pubmed: 26819044
Sci Adv. 2017 Mar 08;3(3):e1601314
pubmed: 28345030
Expert Rev Endocrinol Metab. 2018 Mar;13(2):63-65
pubmed: 30058860
Nature. 2016 Dec 14;540(7633):379-385
pubmed: 27974769
Hum Genomics. 2012 Oct 10;6:22
pubmed: 23157966
J Diabetes Sci Technol. 2009 Jul 01;3(4):863-74
pubmed: 20144336
Sci Adv. 2018 Nov 09;4(11):eaas9530
pubmed: 30430132
ACS Nano. 2017 Oct 24;11(10):10032-10041
pubmed: 28837773
Nat Nanotechnol. 2016 Jun;11(6):566-572
pubmed: 26999482
Ocul Surf. 2007 Oct;5(4):280-93
pubmed: 17938838
ACS Appl Mater Interfaces. 2018 Feb 28;10(8):7107-7116
pubmed: 29406691
Nature. 2017 Sep 20;549(7672):328-330
pubmed: 28933443
Soft Matter. 2015 Feb 7;11(5):882-8
pubmed: 25466584
Nat Biotechnol. 2006 Apr;24(4):437-8
pubmed: 16531991
Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G743-G751
pubmed: 30048596
Biomaterials. 2008 May;29(14):2259-69
pubmed: 18289662
Adv Healthc Mater. 2015 Apr 22;4(6):792-810
pubmed: 25400274
Nat Mater. 2011 Apr;10(4):316-23
pubmed: 21378969
IEEE Trans Biomed Circuits Syst. 2017 Jun;11(3):523-533
pubmed: 28371784