Inhibition of phosphatidylinositol kinase-III alpha induces or facilitates lysosome exocytosis from microglia.
Journal
Neuroreport
ISSN: 1473-558X
Titre abrégé: Neuroreport
Pays: England
ID NLM: 9100935
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
pubmed:
20
5
2020
medline:
19
8
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
Besides degradation, lysosomes can also carry molecules for secretion out of the cell, such as ATP and cytokines, during unconventional secretion. Phosphatidylinositols and their metabolizing enzymes play important roles in the sorting and trafficking of lysosomal materials through the trans-Golgi network. The present study reveals a new function of phosphatidylinositol kinase-III alpha in the 'kiss-and-run' fusion of lysosomes at the plasma membrane to release ATP from microglia.
Identifiants
pubmed: 32427802
doi: 10.1097/WNR.0000000000001348
pii: 00001756-202007010-00001
doi:
Substances chimiques
Adenosine Triphosphate
8L70Q75FXE
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
697-701Références
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