Atomic-Scale Description of Interfaces between Antigen and Aluminum-Based Adjuvants Used in Vaccines by Dynamic Nuclear Polarization (DNP) Enhanced NMR Spectroscopy.
NMR spectroscopy
aluminium
noncovalent interactions
phosphorus
vaccine formulations
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
22 Jul 2020
22 Jul 2020
Historique:
received:
05
03
2020
pubmed:
20
5
2020
medline:
23
9
2020
entrez:
20
5
2020
Statut:
ppublish
Résumé
The addition of aluminum-based adjuvants in vaccines enhances the immune response to antigens. The strength of antigen adsorption on adjuvant gels is known to modulate vaccine efficacy. However, a detailed understanding of the mechanisms of interaction between aluminum gels and antigens is still missing. Herein, a new analytical approach based on dynamic nuclear polarization (DNP) enhanced NMR spectroscopy under magic angle spinning (MAS) is implemented to provide a molecular description of the antigen-adjuvant interface. This approach is demonstrated on hepatitis B surface antigen particles in combination with three aluminum gels obtained from different suppliers. Both noncovalent and covalent interactions between the phospholipids of the antigen particles and the surface of the aluminum gels are identified by using MAS DNP NMR
Identifiants
pubmed: 32428253
doi: 10.1002/chem.202001141
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antigens
0
Vaccines
0
Aluminum
CPD4NFA903
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8976-8982Subventions
Organisme : agence nationale de la recherche
ID : ANR- 17-CE29-0006-01
Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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