Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography.

Blood-Brain Barrier Drug Delivery Systems Female Humans Male Microbubbles Pharmaceutical Preparations Positron-Emission Tomography
Blood-brain barrier transporters FUS Microbubbles Radiotracers

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 08 2020
Historique:
received: 20 02 2020
revised: 13 05 2020
accepted: 14 05 2020
pubmed: 20 5 2020
medline: 22 6 2021
entrez: 20 5 2020
Statut: ppublish

Résumé

Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism.

Identifiants

DOI: 10.1016/j.jconrel.2020.05.020 PMID: 32428519
pubmed: 32428519
pii: S0168-3659(20)30297-2
doi: 10.1016/j.jconrel.2020.05.020
pii:
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

303-316

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Wejdan M Arif (WM)

University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; King Saud University, College of Applied Medical Science, Department of Radiological Sciences, Riyadh, Saudi Arabia.

Philip H Elsinga (PH)

University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.

Carmen Gasca-Salas (C)

Centre for Integrative Neuroscience AC, HM Puerta del Sur, CEU San Pablo University, Madrid, Spain; Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain.

Michel Versluis (M)

Multimodality Medical Imaging M3i Group, Technical Medical (TechMed) Center, University of Twente, Enschede, the Netherlands; Physics of Fluids Group, Technical Medical (TechMed) Center, University of Twente, Enschede, the Netherlands.

Raul Martínez-Fernández (R)

Centre for Integrative Neuroscience AC, HM Puerta del Sur, CEU San Pablo University, Madrid, Spain; Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain.

Rudi A J O Dierckx (RAJO)

University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.

Ronald J H Borra (RJH)

University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.

Gert Luurtsema (G)

University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713 GZ Groningen, the Netherlands. Electronic address: g.luurtsema@umcg.nl.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Focused ultrasound for opening blood-brain...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Focused ultrasound for opening blood-brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Focused ultrasound for opening blood-brain...
questionsmedicales.fr › Équipement et fournitures › Microbulles › Focused ultrasound for opening blood-brain...
questionsmedicales.fr › Préparations pharmaceutiques › Focused ultrasound for opening blood-brain...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Focused ultrasound for opening blood-brain...