The thrombotic risk of spaceflight: has a serious problem been overlooked for more than half of a century?
Aging
Astronaut
Commercial spaceflight
Exploration mission
Human spaceflight
International Space Station
Mars
Microgravity
Moon
Thrombotic risk
Touristic spaceflight
Weightlessness
Journal
European heart journal
ISSN: 1522-9645
Titre abrégé: Eur Heart J
Pays: England
ID NLM: 8006263
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
18
12
2019
revised:
12
02
2020
accepted:
20
04
2020
pubmed:
20
5
2020
medline:
15
5
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
The first ever venous thrombotic condition associated with spaceflight, an internal jugular vein thrombus requiring anticoagulation, has recently been reported. Systematic investigation of space travel-associated thrombotic risk has not been conducted. Cellular, animal, and human studies performed in ground-based models and in actual weightlessness revealed influences of weightlessness and gravity on the blood coagulation system. However, human study populations were small and limited to highly selected participants. Evidence in individuals with medical conditions and older persons is lacking. Evidence for thrombotic risk in spaceflight is unsatisfactory. This issue deserves further study in heterogeneous, high risk populations to find prevention strategies and to enable safe governmental and touristic human spaceflight.
Identifiants
pubmed: 32428936
pii: 5840773
doi: 10.1093/eurheartj/ehaa359
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-100Informations de copyright
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.