Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.

BRCA1 BRCA2 BRIP1 RAD51C RAD51D SNP ovarian cancer risk population genetic testing risk modelling risk stratification

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
15 May 2020
Historique:
received: 01 04 2020
revised: 01 05 2020
accepted: 06 05 2020
entrez: 21 5 2020
pubmed: 21 5 2020
medline: 21 5 2020
Statut: epublish

Résumé

Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification of general population women using a personalised OC risk tool followed by risk management. Volunteers were recruited through London primary care networks. women ≥18 years. prior ovarian/tubal/peritoneal cancer, previous genetic testing for OC genes. Participants accessed an online/web-based decision aid along with optional telephone helpline use. Consenting individuals completed risk assessment and underwent genetic testing ( feasibility/acceptability, uptake, decision aid/telephone helpline use, satisfaction/regret, and impact on psychological health/quality of life. In total, 123 volunteers (mean age = 48.5 (SD = 15.4) years) used the decision aid, 105 (85%) consented. None fulfilled NHS genetic testing clinical criteria. OC risk stratification revealed 1/103 at ≥10% (high), 0/103 at ≥5%-<10% (intermediate), and 100/103 at <5% (low) lifetime OC risk. Decision aid satisfaction was 92.2%. The telephone helpline use rate was 13% and the questionnaire response rate at six months was 75%. Contrast tests indicated that overall depression (

Identifiants

DOI: 10.3390/cancers12051241 PMID: 32429029 PMC: PMC7281662
pubmed: 32429029
pii: cancers12051241
doi: 10.3390/cancers12051241
pmc: PMC7281662
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Medical Research Council
ID : MC_UU_12023/28
Pays : United Kingdom
Organisme : The Eve Appeal Charity
ID : C16420/A18066
Organisme : Cancer Research UK
ID : C16420/A18066
Pays : United Kingdom

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Auteurs

Faiza Gaba (F)

Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Department of Gynaecological Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.
ORCID: 0000-0003-4081-6883

Oleg Blyuss (O)

School of Physics, Astronomy and Mathematics, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK.
Department of Paediatrics and Paediatric Infectious Diseases, Sechenov First Moscow State Medical University, Moscow 119146, Russia.
Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603098, Russia.

Xinting Liu (X)

Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
ORCID: 0000-0002-7475-0096

Shivam Goyal (S)

Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Nishant Lahoti (N)

Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Dhivya Chandrasekaran (D)

Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Department of Gynaecological Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.

Margarida Kurzer (M)

Department of Gynaecological Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.

Jatinderpal Kalsi (J)

Department of Women's Cancer, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London WC1E 6AU, UK.

Saskia Sanderson (S)

Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
ORCID: 0000-0001-8427-724X

Anne Lanceley (A)

Department of Women's Cancer, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London WC1E 6AU, UK.

Munaza Ahmed (M)

Department Clinical Genetics, North East Thames Regional Genetics Unit, Great Ormond Street Hospital, London WC1N 3JH, UK.

Lucy Side (L)

Department of Clinical Genetics, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.

Aleksandra Gentry-Maharaj (A)

Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, 90 High Holborn, London WC1V 6LJ, UK.

Yvonne Wallis (Y)

West Midlands Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust, Birmingham B15 2TG, UK.

Andrew Wallace (A)

Manchester Centre for Genomic Medicine, 6th Floor Saint Marys Hospital, Oxford Rd, Manchester M13 9WL, UK.

Jo Waller (J)

Cancer Prevention Group, King's College London, Great Maze Pond, London SE1 9RT, UK.

Craig Luccarini (C)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.

Xin Yang (X)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.
ORCID: 0000-0003-4591-1214

Alison Dunning (A)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.

Andrew Lee (A)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.

Antonis C Antoniou (AC)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.

Rosa Legood (R)

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

Usha Menon (U)

Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, 90 High Holborn, London WC1V 6LJ, UK.
ORCID: 0000-0003-3708-1732

Ian Jacobs (I)

Department of Women's Health, University of New South Wales, Australia, Level 1, Chancellery Building, Sydney 2052, Australia.

Ranjit Manchanda (R)

Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Department of Gynaecological Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.
Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, 90 High Holborn, London WC1V 6LJ, UK.
ORCID: 0000-0003-3381-5057

Classifications MeSH