Non-Coding RNAs: Regulating Disease Progression and Therapy Resistance in Hepatocellular Carcinoma.
hepatocellular carcinoma
non-coding RNA
therapy resistance
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
17
04
2020
revised:
12
05
2020
accepted:
12
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC), the primary liver cancer arising from hepatocytes, is a universal health problem and one of the most common malignant tumors. Surgery followed by chemotherapy as well as tyrosine kinase inhibitors (TKIs), such as sorafenib, are primary treatment procedures for HCC, but recurrence of disease because of therapy resistance results in high mortality. It is necessary to identify novel regulators of HCC for developing effective targeted therapies that can significantly interfere with progression of the disease process. Non-coding RNAs (ncRNAs) are an abundant group of versatile RNA transcripts that do not translate into proteins, rather serve as potentially functional RNAs. The role of ncRNAs in regulating diverse aspects of the carcinogenesis process are gradually being elucidated. Recent advances in RNA sequencing technology have identified a plethora of ncRNAs regulating all aspects of hepatocarcinogenesis process and serving as potential prognostic or diagnostic biomarkers. The present review provides a comprehensive description of the biological roles of ncRNAs in disease process and therapy resistance, and potential clinical application of these ncRNAs in HCC.
Identifiants
pubmed: 32429062
pii: cancers12051243
doi: 10.3390/cancers12051243
pmc: PMC7281199
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA230561
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA244993
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240004
Pays : United States
Organisme : NIDDK NIH HHS
ID : 1R01DK107451-01A1
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107451
Pays : United States
Organisme : NCI NIH HHS
ID : 1R01CA230561-01A1, 1R01CA240004-01, 1R01CA244993-01
Pays : United States
Organisme : U.S. Department of Defense
ID : CA170048
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