Characterization of Stem-like Circulating Tumor Cells in Pancreatic Cancer.
CTC
EMT
PDAC
adherens junctions
circulating tumor cells
epithelial-mesenchymal transition
pancreatic cancer
stem cells
stem-like
stemness
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
17
02
2020
revised:
26
04
2020
accepted:
13
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most frequent cause of death from cancer. Circulating tumor cells (CTCs) with stem-like characteristics lead to distant metastases and thus contribute to the dismal prognosis of PDAC. Our purpose is to investigate the role of stemness in CTCs derived from a genetically engineered mouse model of PDAC and to further explore the potential molecular mechanisms. The publically available RNA sequencing dataset GSE51372 was analyzed, and CTCs with (CTC-S) or without (CTC-N) stem-like features were discriminated based on a principal component analysis (PCA). Differentially expressed genes, weighted gene co-expression network analysis (WGCNA), and further functional enrichment analyses were performed. The prognostic role of the candidate gene (
Identifiants
pubmed: 32429174
pii: diagnostics10050305
doi: 10.3390/diagnostics10050305
pmc: PMC7278018
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : China Scholarship Council
ID : 201908080072
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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