High Nanodiamond Content-PCL Composite for Tissue Engineering Scaffolds.
3D-printed scaffold
composite
nanodiamond
polycaprolactone
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
15 May 2020
15 May 2020
Historique:
received:
26
04
2020
revised:
13
05
2020
accepted:
13
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
Multifunctional scaffolds are becoming increasingly important in the field of tissue engineering. In this research, a composite material is developed using polycaprolactone (PCL) and detonation nanodiamond (ND) to take advantage of the unique properties of ND and the biodegradability of PCL polymer. Different ND loading concentrations are investigated, and the physicochemical properties of the composites are characterized. ND-PCL composite films show a higher surface roughness and hydrophilicity than PCL alone, with a slight decrease in tensile strength and a significant increase in degradation. Higher loading of ND also shows a higher osteoblast adhesion than the PCL alone sample. Finally, we show that the ND-PCL composites are successfully extruded to create a 3D scaffold demonstrating their potential as a composite material for tissue regeneration.
Identifiants
pubmed: 32429310
pii: nano10050948
doi: 10.3390/nano10050948
pmc: PMC7279315
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Clive and Vera Ramaciotti Foundation and the CASS Foundation (Medicine and Science)
ID : N/A.
Organisme : Advance Queensland Research Fellowship (AQRF04816-17RD2) and QUT's Vice Chancellor Research Fellowship.
ID : AQRF04816-17RD2
Déclaration de conflit d'intérêts
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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