Epigenetic Regulation of Alternative mRNA Splicing in Dilated Cardiomyopathy.
DNA methylation
alternative splicing
dilated cardiomyopathy
epigenetics
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
16 May 2020
16 May 2020
Historique:
received:
10
03
2020
revised:
04
05
2020
accepted:
12
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
In recent years, the genetic architecture of dilated cardiomyopathy (DCM) has been more thoroughly elucidated. However, there is still insufficient knowledge on the modifiers and regulatory principles that lead to the failure of myocardial function. The current study investigates the association of epigenome-wide DNA methylation and alternative splicing, both of which are important regulatory principles in DCM. We analyzed screening and replication cohorts of cases and controls and identified distinct transcriptomic patterns in the myocardium that differ significantly, and we identified a strong association of intronic DNA methylation and flanking exons usage (
Identifiants
pubmed: 32429430
pii: jcm9051499
doi: 10.3390/jcm9051499
pmc: PMC7291244
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Eur Heart J. 2017 Dec 7;38(46):3449-3460
pubmed: 29029073
J Am Heart Assoc. 2017 Dec 20;6(12):
pubmed: 29263036
Genome Biol. 2017 Jun 19;18(1):120
pubmed: 28629478
Clin Res Cardiol. 2017 Feb;106(2):127-139
pubmed: 27576561
EMBO Mol Med. 2015 Mar 09;7(5):562-76
pubmed: 25759365
Eur Rev Med Pharmacol Sci. 2019 Dec;23(24):10678-10684
pubmed: 31858535
N Engl J Med. 2012 Feb 16;366(7):619-28
pubmed: 22335739
Science. 2001 Dec 7;294(5549):2113-5
pubmed: 11739943
Elife. 2016 May 10;5:
pubmed: 27162171
Cardiovasc Res. 2016 Oct;112(1):452-63
pubmed: 27496873
Cell Res. 2013 Nov;23(11):1256-69
pubmed: 23938295
Nature. 2014 Oct 2;514(7520):102-106
pubmed: 25119045
Circ Res. 2015 Feb 13;116(4):751-62
pubmed: 25677521
Nat Rev Genet. 2009 May;10(5):295-304
pubmed: 19308066
IEEE/ACM Trans Comput Biol Bioinform. 2014 Mar-Apr;11(2):375-88
pubmed: 26355784
PLoS Comput Biol. 2013;9(8):e1003118
pubmed: 23950696
Genome Res. 2012 Dec;22(12):2497-506
pubmed: 22960375
Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H674-H684
pubmed: 31298559
Circ Cardiovasc Genet. 2016 Oct;9(5):419-425
pubmed: 27625338
Nat Genet. 2017 Jan;49(1):46-53
pubmed: 27869827
Ann Thorac Surg. 2017 Nov;104(5):1531-1539
pubmed: 28760462
Nat Rev Cardiol. 2013 Sep;10(9):531-47
pubmed: 23900355
Genome Biol. 2014;15(12):550
pubmed: 25516281
Circ Res. 2017 Sep 15;121(7):731-748
pubmed: 28912180
Sci Transl Med. 2015 Jan 14;7(270):270ra6
pubmed: 25589632
Epigenomics. 2013 Aug;5(4):351-3
pubmed: 23895647
J Mol Cell Cardiol. 2019 Jun;131:12-19
pubmed: 30998980
Life Sci. 2020 Mar 1;244:116936
pubmed: 31610194
Nat Genet. 2003 Jun;34(2):187-92
pubmed: 12740577
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
J Mol Cell Cardiol. 2015 Dec;89(Pt A):27-34
pubmed: 26546166
Biochim Biophys Acta. 2013 Apr;1833(4):923-33
pubmed: 22951218
Nature. 2006 Feb 16;439(7078):871-4
pubmed: 16357870
Nat Genet. 2007 Feb;39(2):232-6
pubmed: 17200670
Cell. 2011 Jan 7;144(1):16-26
pubmed: 21215366
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2956-2962
pubmed: 30135013
Nature. 2002 Jan 10;415(6868):227-33
pubmed: 11805847
Trends Genet. 2015 May;31(5):274-80
pubmed: 25837375
PLoS Comput Biol. 2012;8(12):e1002822
pubmed: 23300413
Cell Rep. 2015 Feb 24;10(7):1122-34
pubmed: 25704815
PLoS One. 2015 Apr 02;10(3):e0121945
pubmed: 25835001
EMBO Mol Med. 2018 Jan;10(1):107-120
pubmed: 29138229
Cell. 2007 Feb 23;128(4):669-81
pubmed: 17320505
Circulation. 2013 Dec 24;128(25):2813-51
pubmed: 24297835
Mol Med Rep. 2018 Feb;17(2):2695-2704
pubmed: 29207090
Circulation. 2017 Oct 17;136(16):1528-1544
pubmed: 28838933
Nucleic Acids Res. 2013 Oct;41(18):8503-14
pubmed: 23887936
Genome Res. 2012 Oct;22(10):2008-17
pubmed: 22722343
Nature. 2010 Jul 15;466(7304):388-92
pubmed: 20512117
J Gene Med. 2019 May;21(5):e3083
pubmed: 30811764
Curr Cardiol Rep. 2018 Aug 13;20(10):83
pubmed: 30105555
Nature. 2011 Nov 3;479(7371):74-9
pubmed: 21964334
Biochem Biophys Res Commun. 2008 Sep 26;374(3):559-64
pubmed: 18656446
Curr Protoc Hum Genet. 2015 Oct 06;87:11.16.1-11.16.14
pubmed: 26439713
PLoS Genet. 2012 Sep;8(9):e1002956
pubmed: 23028363
Genes Dev. 1988 Jun;2(6):754-65
pubmed: 3138163
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Science. 2004 Oct 22;306(5696):647-50
pubmed: 15499010
Neoplasma. 2019 Jul 23;66(4):564-575
pubmed: 30943745
Nature. 2007 Jun 7;447(7145):655-60
pubmed: 17554299
Bioinformatics. 2016 May 15;32(10):1502-8
pubmed: 26787660
Cell Death Dis. 2019 Jul 30;10(8):573
pubmed: 31363080
Clin Cancer Res. 2018 Jan 15;24(2):486-498
pubmed: 29101304