Hematological Diseases and Osteoporosis.
hemophilia
mastocytosis
monoclonal gammopathy of undetermined significance (MGUS)
multiple myeloma
osteoporosis
thalassemia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 May 2020
16 May 2020
Historique:
received:
29
04
2020
revised:
14
05
2020
accepted:
14
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Secondary osteoporosis is a common clinical problem faced by bone specialists, with a higher frequency in men than in women. One of several causes of secondary osteoporosis is hematological disease. There are numerous hematological diseases that can have a deleterious impact on bone health. In the literature, there is an abundance of evidence of bone involvement in patients affected by multiple myeloma, systemic mastocytosis, thalassemia, and hemophilia; some skeletal disorders are also reported in sickle cell disease. Recently, monoclonal gammopathy of undetermined significance appears to increase fracture risk, predominantly in male subjects. The pathogenetic mechanisms responsible for these bone loss effects have not yet been completely clarified. Many soluble factors, in particular cytokines that regulate bone metabolism, appear to play an important role. An integrated approach to these hematological diseases, with the help of a bone specialist, could reduce the bone fracture rate and improve the quality of life of these patients.
Identifiants
pubmed: 32429497
pii: ijms21103538
doi: 10.3390/ijms21103538
pmc: PMC7279036
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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