The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target.
COVID-19
SARS-COV-2
coronavirus
endocytosis
lipid metabolism
sphingolipid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 May 2020
17 May 2020
Historique:
received:
21
04
2020
revised:
08
05
2020
accepted:
08
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
22
5
2020
Statut:
epublish
Résumé
The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million people and resulted in the death of over one hundred thousand people at the time of writing this review. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though multiple vaccines and treatments are under development so far, the disease is only slowing down under extreme social distancing measures that are difficult to maintain. SARS-COV-2 is an enveloped virus that is surrounded by a lipid bilayer. Lipids are fundamental cell components that play various biological roles ranging from being a structural building block to a signaling molecule as well as a central energy store. The role lipids play in viral infection involves the fusion of the viral membrane to the host cell, viral replication, and viral endocytosis and exocytosis. Since lipids play a crucial function in the viral life cycle, we asked whether drugs targeting lipid metabolism, such as statins, can be utilized against SARS-CoV-2 and other viruses. In this review, we discuss the role of lipid metabolism in viral infection as well as the possibility of targeting lipid metabolism to interfere with the viral life cycle.
Identifiants
pubmed: 32429572
pii: ijms21103544
doi: 10.3390/ijms21103544
pmc: PMC7278986
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Dasman Diabetes Institute
ID : RA 2016-025
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