A host-guest drug delivery nanosystem for supramolecular chemotherapy.
Calixarene
Drug delivery
Macrocyclic amphiphiles
Molecular recognition
Supramolecular chemotherapy
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
10 08 2020
10 08 2020
Historique:
received:
11
12
2019
revised:
01
05
2020
accepted:
04
05
2020
pubmed:
21
5
2020
medline:
22
6
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Supramolecular chemotherapy is currently a new strategy to improve the therapeutic efficacy as well as overcome the side effects of traditional chemotherapy. Herein, a supramolecular chemotherapy platform based on the pegylated guanidinium-modified calix[5]arene pentadodecyl ether (GC5A-12C) nanoassembly was prepared. Three commercially available antitumor drugs: oxaliplatin, methotrexate and chlorambucil, all showed strong binding to this GC5A-12C nanocarrier. The supramolecular nanodrugs achieved higher anticancer performances compared with free drugs in cell experiments. Furthermore, the cellular uptake mechanisms and efficacy are confirmed by fluorescence imaging.
Identifiants
pubmed: 32430277
pii: S0168-3659(20)30283-2
doi: 10.1016/j.jconrel.2020.05.008
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Pharmaceutical Preparations
0
Oxaliplatin
04ZR38536J
Methotrexate
YL5FZ2Y5U1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
124-133Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.