Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
30
11
2018
accepted:
20
04
2020
pubmed:
21
5
2020
medline:
22
6
2021
entrez:
21
5
2020
Statut:
epublish
Résumé
Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community.
Identifiants
pubmed: 32430415
pii: 13993003.02320-2019
doi: 10.1183/13993003.02320-2019
pmc: PMC7439216
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT03165656']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: R. Gosens reports grants from Novartis, Boehringer Ingelheim, Aquilo and Chiesi, outside the submitted work. Conflict of interest: P.S. Hiemstra reports grants from Boehringer Ingelheim and Galapagos N.V., outside the submitted work. Conflict of interest: I.M. Adcock reports personal fees for lectures from AstraZeneca and Sunovion, grants from Boehringer Ingelheim, outside the submitted work. Conflict of interest: K.R. Bracke has nothing to disclose. Conflict of interest: R.P. Dickson has nothing to disclose. Conflict of interest: P.M. Hansbro has nothing to disclose. Conflict of interest: S. Krauss-Etschmann has nothing to disclose. Conflict of interest: H.H. Smits has nothing to disclose. Conflict of interest: F.R.M. Stassen has nothing to disclose. Conflict of interest: S. Bartel reports grants and personal fees for advisory board work from Bencard Allergie GmbH, outside the submitted work.
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