Fibronodular hepatocellular carcinoma-a new variant of liver cancer: clinical, pathological and radiological correlation.
Aged
Carcinoma, Hepatocellular
/ diagnostic imaging
Cohort Studies
Connecticut
Disease Progression
Female
Humans
Image Processing, Computer-Assisted
Liver
/ diagnostic imaging
Liver Cirrhosis
/ diagnostic imaging
Liver Neoplasms
/ diagnostic imaging
Male
Middle Aged
Radiography
Retrospective Studies
classification
diagnostic techniques and procedures
liver
liver neoplasms
Journal
Journal of clinical pathology
ISSN: 1472-4146
Titre abrégé: J Clin Pathol
Pays: England
ID NLM: 0376601
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
14
03
2020
revised:
21
04
2020
accepted:
23
04
2020
pubmed:
21
5
2020
medline:
5
1
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
To establish and define a new, not previously reported hepatocellular carcinoma (HCC) variant, termed fibronodular HCC (FN-HCC). We retrospectively reviewed 290 HCC cases and identified 29 FN-HCC and 24 scirrhous HCC (SCHCC). Clinical, pathological and radiological features of FN-HCC were reviewed and compared with 30 conventional HCCs (CV-HCC) and SC-HCC. FN-HCCs were more likely to arise in non-advanced fibrotic livers with lower advanced Barcelona Clinic Liver Cancer (BCLC) stage, had lower rates of progression and longer time to progression and were more likely to be surgically resected compared with CV-HCCs and SC-HCCs. Imaging analysis of FN-HCCs demonstrated higher rates of non-peripheral washout and a new distinct pattern of enhancement which is characterised by the presence of multiple rounded nodules within a lesion embedded in fibrotic-appearing parenchyma. FN-HCC may represent a specific variant of HCC with distinct pathological, radiological and clinical features with potential ramifications for outcome.
Identifiants
pubmed: 32430483
pii: jclinpath-2020-206574
doi: 10.1136/jclinpath-2020-206574
pmc: PMC7674234
mid: NIHMS1597174
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
31-35Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK034989
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206180
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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