Synthesis, in vitro and in vivo evaluation of
5-HT1A receptor
Carbon-11
PET
Serotonin
α1-adrenergic receptor
Journal
EJNMMI radiopharmacy and chemistry
ISSN: 2365-421X
Titre abrégé: EJNMMI Radiopharm Chem
Pays: England
ID NLM: 101714628
Informations de publication
Date de publication:
19 May 2020
19 May 2020
Historique:
received:
11
02
2020
accepted:
23
04
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
Serotonin 1A (5-HT Syntheses of 1-3 and corresponding precursors for radiolabeling were achieved from isonicotinic, picolinic acid or picolino nitrile. In vitro binding studies demonstrated nanomolar affinity of the compounds for 5-HT Despite efficient radiolabeling, results from PET imaging experiments limit the application of [
Sections du résumé
BACKGROUND
BACKGROUND
Serotonin 1A (5-HT
RESULTS
RESULTS
Syntheses of 1-3 and corresponding precursors for radiolabeling were achieved from isonicotinic, picolinic acid or picolino nitrile. In vitro binding studies demonstrated nanomolar affinity of the compounds for 5-HT
CONCLUSION
CONCLUSIONS
Despite efficient radiolabeling, results from PET imaging experiments limit the application of [
Identifiants
pubmed: 32430632
doi: 10.1186/s41181-020-00096-8
pii: 10.1186/s41181-020-00096-8
pmc: PMC7237647
doi:
Types de publication
Journal Article
Langues
eng
Pagination
13Subventions
Organisme : NIH HHS
ID : R01AG054473
Pays : United States
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