Acute Glucose Load, Inflammation, Oxidative Stress, Nonenzymatic Glycation, and Screening for Gestational Diabetes.
RAGE
advanced glycation end products
diabetes
glucose
pregnancy
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
21
5
2020
medline:
15
12
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
To investigate if oral glucose tolerance test (OGTT) associates with changes in maternal symptoms (ie, flushing, sweating), blood nonenzymatic advanced glycation end products (AGE), acute-phase reactive inflammatory markers, and oxidative stress. Prospective case-control study of patients screened for gestational diabetes mellitus (GDM). One hundred nonfasting, second-trimester consecutive pregnant women allocated to either 50 g OGTT or water. Five women who had a 3-hour fasting 100 g OGTT also enrolled. Maternal serum glucose, AGE, soluble receptor for AGE (sRAGE), interleukin (IL)-6, and C-reactive protein (CRP) were immunoassayed. Total radical-trapping antioxidant parameter (TRAP) estimated with antioxidant capacityperoxyl assay. Data corrected for gestational age and maternal body mass index. During 50 g OGTT there was a decrease in systolic blood pressure not accompanied by the onset of adverse clinical symptoms. There was a decrease in serum glucose levels 1 hour after water (P = .019) but not glucose ingestion. Serum CRP (P = .001) but not IL-6 was increased. The AGE, sRAGE, and TRAP levels remained unchanged. Similar results were seen during 100 g OGTT, except serum glucose was significantly elevated after 1 hour. Results suggest screening tools for gestational diabetes are safe and clinically well tolerated during pregnancy. ClinicalTrials.gov NCT03029546.
Identifiants
pubmed: 32430709
doi: 10.1007/s43032-020-00188-5
pii: 10.1007/s43032-020-00188-5
doi:
Substances chimiques
Glycation End Products, Advanced
0
Glucose
IY9XDZ35W2
Banques de données
ClinicalTrials.gov
['NCT03029546']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1587-1594Références
Wilkerson HL, O’Sullivan JB. A study of glucose tolerance and screening criteria in 752 unselected pregnancies. Diabetes. 1963;12:313–8.
pubmed: 14081842
doi: 10.2337/diab.12.4.313
National Health and Nutrition Examination Survey (NHANES). Oral Glucose Tolerance Test (OGTT) Procedures Manual. Atlanta: Centers for Disease Control and Prevention, National Center for Health Statistics; 2007.
Andrade HF, Pedrosa W, Diniz Mde F, Passos VM. Adverse effects during the oral glucose tolerance test in post-bariatric surgery patients. Arch Endocrinol Metab. 2016;60(4):307–13.
pubmed: 26910630
doi: 10.1590/2359-3997000000149
Buhimschi IA, Zhao G, Pettker CM, et al. The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation. Am J Obstet Gynecol. 2007;196(2):181.e1-181.e13.
Chavakis T, Bierhaus A, Nawroth PP. RAGE (receptor for advanced glycation end products): a central player in the inflammatory response. Microbes Infect. 2004;6(13):1219–25.
pubmed: 15488742
doi: 10.1016/j.micinf.2004.08.004
Forbes JM, Sourris KC, de Courten MP, et al. Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects. Amino Acids. 2014;46(2):321–6.
pubmed: 23832534
doi: 10.1007/s00726-013-1542-9
Tan KC, Shiu SW, Wong Y, Tam X. Serum advanced glycation end products (AGEs) are associated with insulin resistance. Diabetes Metab Res Rev. 2011;27(5):488–92.
pubmed: 21337488
doi: 10.1002/dmrr.1188
Choi KM, Yoo HG, Kim HY, et al. Association between endogenous secretory RAGE, inflammatory markers and arterial stiffness. Int J Cardiol. 2009;132(1):96–101.
pubmed: 18190981
doi: 10.1016/j.ijcard.2007.10.047
Baynes JW, Thorpe SR. Glycoxidation and lipoxidation in atherogenesis. Free Radic Biol Med. 2000;28(12):1708–16.
pubmed: 10946212
doi: 10.1016/S0891-5849(00)00228-8
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A. Role of advanced glycation end products in cellular signaling. Redox Biol. 2014;2:411–29.
pubmed: 24624331
pmcid: 3949097
doi: 10.1016/j.redox.2013.12.016
Jensen LJ, Flyvbjerg A, Bjerre M. Soluble receptor for advanced glycation end product: a biomarker for acute coronary syndrome. Biomed Res Int. 2015. https://doi.org/10.1155/2015/815942 .
Willemsen S, Hartog JW, van Veldhuisen DJ, et al. The role of advanced glycation end-products and their receptor on outcome in heart failure patients with preserved and reduced ejection fraction. Am Heart J. 2012;164(5):742-749.e3. doi: https://doi.org/10.1016/j.ahj.2012.07.027 .
Kierdorf K, Fritz G. RAGE regulation and signaling in inflammation and beyond. J Leukoc Biol. 2013;94(1):55–68.
pubmed: 23543766
doi: 10.1189/jlb.1012519
Bartakova V, Kollarova R, Kuricova K, Sebekova K, Belobradkova J, Kankova K. Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016;160(1):70–5.
pubmed: 26607295
doi: 10.5507/bp.2015.045
Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 190, February 2018: gestational diabetes mellitus. Obstet Gynecol. 2018;131(2):e49-e64. doi: https://doi.org/10.1097/AOG.0000000000002501 .
Vandorsten JP, Dodson WC, Espeland MA, et al. NIH consensus development conference: diagnosing gestational diabetes mellitus. NIH Consens State Sci State. 2013;29(1):1–31.
Jabaudon M, Blondonnet R, Roszyk L, et al. Soluble forms and ligands of the receptor for advanced glycation end-products in patients with acute respiratory distress syndrome: an observational prospective study. PLoS One. 2015;10(8):e0135857.
Williams MA, Enquobahrie DA, Zimmer J, et al. Maternal plasma advanced glycation end products concentrations in response to oral 50-gram glucose load in mid-pregnancy: a pilot study. Clin Lab. 2012;58(9-10):1045–50.
pubmed: 23163122
Kobayashi R, Hashimoto Y, Hatakeyama H, Okamoto T. Acute effects of repeated bouts of aerobic exercise on arterial stiffness after glucose ingestion. Clin Exp Hypertens. 2019;41(2):123–9. https://doi.org/10.1080/10641963.2018.1451535 .
pubmed: 29565685
doi: 10.1080/10641963.2018.1451535
Martineau MG, Raker C, Dixon PH, et al. The metabolic profile of intrahepatic cholestasis of pregnancy is associated with impaired glucose tolerance, dyslipidemia, and increased fetal growth. Diabetes Care. 2015;38(2):243–8.
pubmed: 25504029
doi: 10.2337/dc14-2143
Bank S, Jackson WP, Keller P, Marks IN. Serum-insulin response to glucose in “pancreatic diabetes”. Postgrad Med J. 1968; 44(509):214-217.
Schwartz JG, Phillips WT, Blumhardt MR, Langer O. Use of a more physiologic oral glucose solution during screening for gestational diabetes mellitus. Am J Obstet Gynecol. 1994;171(3):685–91.
pubmed: 8092215
doi: 10.1016/0002-9378(94)90082-5
Brown MA, Robinson A, Jones M. The white coat effect in hypertensive pregnancy: much ado about nothing? Br J Obstet Gynaecol. 1999;106(5):474–80.
pubmed: 10430198
doi: 10.1111/j.1471-0528.1999.tb08301.x
Walsh LK, Restaino RM, Neuringer M, Manrique C, Padilla J. Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. Clin Sci (Lond). 2016;130(21):1881–8.
pubmed: 27503949
pmcid: 5507333
doi: 10.1042/CS20160501
Tack J, Arts J, Caenepeel P, De Wulf D, Bisschops R. Pathophysiology, diagnosis and management of postoperative dumping syndrome. Nat Rev Gastroenterol Hepatol. 2009;6(10):583–90.
pubmed: 19724252
doi: 10.1038/nrgastro.2009.148
Emous M, Wolffenbuttel BHR, Totté E, van Beek AP. The short to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life. Surg Obes Relat Dis. 2017;13(9):1489–500.
pubmed: 28624531
doi: 10.1016/j.soard.2017.04.028
Morris C, O’Grada C, Ryan M, et al. Identification of differential responses to an oral glucose tolerance test in healthy adults. PLoS One. 2013;8(8):e72890.
Takahashi K, Nakamura H, Sato H, Matsuda H, Takada K, Tsuji T. Four plasma glucose and insulin responses to a 75 g OGTT in healthy young Japanese women. J Diabetes Res. 2018. https://doi.org/10.1155/2018/5742497 .
Xu B, Chibber R, Ruggiero D, Kohner E, Ritter J, Ferro A. Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products. FASEB J. 2003;17(10):1289–91.
pubmed: 12738813
doi: 10.1096/fj.02-0490fje
McNulty M, Mahmud A, Feely J. Advanced glycation endproducts and arterial stiffness in hypertension. Am J Hypertens. 2007;20(3):242–7.
pubmed: 17324733
doi: 10.1016/j.amjhyper.2006.08.009
Chen SJ, Aikawa C, Matsui T. Quantitative analysis of methylglyoxal, glyoxal and free advanced glycation end-products in the plasma of Wistar rats during the oral glucose tolerance test. Biol Pharm Bull. 2015;38(2):336–69.
pubmed: 25747995
doi: 10.1248/bpb.b14-00698
Popova EA, Mironova RS, Odjakova MK. Non-enzymatic glycosylation and deglycating enzymes. Biotechnol Equip. 2010;24(3):1928–35.
doi: 10.2478/V10133-010-0066-7
Thorpe SR, Baynes JW. Maillard reaction products in tissue proteins: new products and new perspectives. Amino Acids. 2003;25(3-4):275–81.
pubmed: 14661090
doi: 10.1007/s00726-003-0017-9
FuMX RJR, Jenkins AJ, Lyons TJ, Baynes JW, Thorpe SR. The advanced glycation end product, Nepsilon-(carboxymethyl) lysine, is a product of both lipid peroxidation and glycoxidation reactions. J Biol Chem. 1996;271(17):9982–6.
doi: 10.1074/jbc.271.17.9982
Giardino I, Edelstein D, Brownlee M. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes. J Clin Invest. 1994;94(1):110–7.
pubmed: 8040253
pmcid: 296288
doi: 10.1172/JCI117296
Sage AT, Holtby-Ottenhof S, Shi Y, Damjanovic S, Sharma AM, Werstuck GH. Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells. Obesity (Silver Spring). 2012;20(4):748–55.
doi: 10.1038/oby.2011.144
Karima M, Kantarci A, Ohira T, et al. Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol. 2005;78(4):862–70.
pubmed: 16081595
pmcid: 1249507
doi: 10.1189/jlb.1004583
Omori K, Ohira T, Uchida Y, et al. Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase. J Leukoc Biol. 2008;84(1):292–301.
pubmed: 18390927
pmcid: 2774791
doi: 10.1189/jlb.1207832
Ma SW, Tomlinson B, Benzie IF. A study of the effect of oral glucose loading on plasma oxidant: antioxidant balance in normal subjects. Eur J Nutr. 2005;44(4):250–4.
pubmed: 15309420
doi: 10.1007/s00394-004-0518-7