[Pt(O,O'-acac)(γ-acac)(DMS)]: Alternative Strategies to Overcome Cisplatin-Induced Side Effects and Resistance in T98G Glioma Cells.
Apoptosis
/ drug effects
Brain Neoplasms
/ genetics
Calcium
/ metabolism
Cell Death
/ drug effects
Cell Line, Tumor
Cisplatin
/ adverse effects
Cytoskeleton
/ drug effects
Drug Resistance, Neoplasm
/ drug effects
Endoplasmic Reticulum
/ drug effects
Gene Expression Regulation, Neoplastic
/ drug effects
Glioma
/ genetics
Homeostasis
/ drug effects
Humans
Membrane Potential, Mitochondrial
/ drug effects
Nerve Tissue Proteins
/ metabolism
ORAI1 Protein
/ genetics
Organoplatinum Compounds
/ pharmacology
Plasma Membrane Calcium-Transporting ATPases
/ metabolism
Poly(ADP-ribose) Polymerases
/ metabolism
RNA, Messenger
/ genetics
Apoptosis
Ca2+ signaling
Cisplatin
Pt(O,O'-acac)(γ-acac)(DMS)
T98G glioblastoma cells
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
09
09
2019
accepted:
11
05
2020
pubmed:
21
5
2020
medline:
1
10
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Cisplatin (CDDP) is one of the most effective chemotherapeutic agents, used for the treatment of diverse tumors, including neuroblastoma and glioblastoma. CDDP induces cell death through different apoptotic pathways. Despite its clinical benefits, CDDP causes several side effects and drug resistance.[Pt(O,O'-acac)(γ-acac)(DMS)], namely PtAcacDMS, a new platinum(II) complex containing two acetylacetonate (acac) and a dimethylsulphide (DMS) in the coordination sphere of metal, has been recently synthesized and showed 100 times higher cytotoxicity than CDDP. Additionally, PtAcacDMS was associated to a decreased neurotoxicity in developing rat central nervous system, also displaying great antitumor and antiangiogenic activity both in vivo and in vitro. Thus, based on the knowledge that several chemotherapeutics induce cancer cell death through an aberrant increase in [Ca
Identifiants
pubmed: 32430779
doi: 10.1007/s10571-020-00873-8
pii: 10.1007/s10571-020-00873-8
doi:
Substances chimiques
Nerve Tissue Proteins
0
ORAI1 Protein
0
Organoplatinum Compounds
0
Pt(O,O'-acac)(gamma-acac)(DMS)
0
RNA, Messenger
0
Poly(ADP-ribose) Polymerases
EC 2.4.2.30
Plasma Membrane Calcium-Transporting ATPases
EC 3.6.3.8
Cisplatin
Q20Q21Q62J
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
563-587Commentaires et corrections
Type : ErratumIn
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