Humanized Plasminogen Mouse Model to Study Group A Streptococcus Invasive Disease.
Animals
Antigens, Bacterial
/ metabolism
Bacterial Outer Membrane Proteins
/ metabolism
Bacterial Proteins
/ metabolism
Carrier Proteins
/ metabolism
Disease Models, Animal
Host-Pathogen Interactions
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Plasminogen
/ metabolism
Protein Binding
Streptococcal Infections
/ immunology
Streptococcus pyogenes
/ metabolism
Virulence
Virulence Factors
/ metabolism
Bacterial dissemination and survival
Group A Streptococcus
Humanized plasminogen mouse
Invasive disease
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
9
3
2021
Statut:
ppublish
Résumé
This chapter presents the methodology to carry out infection of humanized plasminogen mice with Group A Streptococcus (GAS). This model of invasive disease has been widely used within the field to study the virulence of different GAS strains, host-pathogen interactions, the importance of particular virulence factors, and preclinical evaluation of novel treatments and vaccines. The model has shown to be highly reproducible and therefore represents an invaluable tool for GAS research.
Identifiants
pubmed: 32430832
doi: 10.1007/978-1-0716-0467-0_24
doi:
Substances chimiques
Antigens, Bacterial
0
Bacterial Outer Membrane Proteins
0
Bacterial Proteins
0
Carrier Proteins
0
Virulence Factors
0
Plasminogen
9001-91-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM