Depletion but Activation of CD56
Function of CD56dimCD16+ NK cells
NK cell subsets
Phenotypic of CD56dimCD16+ NK cells
SFTS index
Severe fever with thrombocytopenia syndrome Virus (SFTSV)
Journal
Virologica Sinica
ISSN: 1995-820X
Titre abrégé: Virol Sin
Pays: Netherlands
ID NLM: 101514185
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
11
08
2019
accepted:
28
02
2020
pubmed:
21
5
2020
medline:
28
9
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality (12%-30%). The mechanism by which the SFTS bunyavirus (SFTSV) causes severe illness remains unclear. To evaluate the phenotypic and functional characteristics of the NK cell subsets in SFTS patients, twenty-nine SFTS patients were sequentially sampled from admission until recovery. Phenotypic and functional characteristics of NK cell subsets in circulating blood were analysed via flow cytometry. Then, correlations between NK cell subset frequencies and the SFTS index (SFTSI) were evaluated in all SFTS patients (15 mild, 14 severe) upon admission. The frequencies of CD56
Identifiants
pubmed: 32430872
doi: 10.1007/s12250-020-00224-3
pii: 10.1007/s12250-020-00224-3
pmc: PMC7736421
doi:
Substances chimiques
CD56 Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
588-598Références
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