Potential effects of curcumin in the treatment of COVID-19 infection.
acute respiratory distress syndrome
curcuminoids
pulmonary fibrosis
viral infection
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
08
04
2020
revised:
24
04
2020
accepted:
07
05
2020
pubmed:
21
5
2020
medline:
1
12
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.
Identifiants
pubmed: 32430996
doi: 10.1002/ptr.6738
pmc: PMC7276879
doi:
Substances chimiques
Curcumin
IT942ZTH98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2911-2920Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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