Atrial Tissue Pro-Fibrotic M2 Macrophage Marker CD163+, Gene Expression of Procollagen and B-Type Natriuretic Peptide.
Aged
Antigens, CD
/ analysis
Antigens, Differentiation, Myelomonocytic
/ analysis
Atrial Fibrillation
/ diagnosis
Atrial Remodeling
Biomarkers
/ analysis
Case-Control Studies
Collagen Type I
/ analysis
Cross-Sectional Studies
Female
Fibrosis
Gene Expression Regulation
Heart Atria
/ chemistry
Humans
Macrophages
/ chemistry
Male
Middle Aged
Natriuretic Peptide, Brain
/ analysis
Phenotype
Procollagen
/ analysis
Receptors, Cell Surface
/ analysis
atrial fibrillation
fibrosis
gene expression
macrophage
natriuretic peptide
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
02 06 2020
02 06 2020
Historique:
pubmed:
21
5
2020
medline:
11
3
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Background Atrial tissue fibrosis is linked to inflammatory cells, yet is incompletely understood. A growing body of literature associates peripheral blood levels of the antifibrotic hormone BNP (B-type natriuretic peptide) with atrial fibrillation (AF). We investigated the relationship between pro-fibrotic tissue M2 macrophage marker Cluster of Differentiation (CD)163+, atrial procollagen expression, and BNP gene expression in patients with and without AF. Methods and Results In a cross-sectional study design, right atrial tissue was procured from 37 consecutive, consenting, stable patients without heart failure or left ventricular systolic dysfunction, of whom 10 had AF and 27 were non-AF controls. Samples were analyzed for BNP and fibro-inflammatory gene expression, as well as fibrosis and CD163+. Primary analyses showed strong correlations (all
Identifiants
pubmed: 32431194
doi: 10.1161/JAHA.119.013416
pmc: PMC7428985
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
Biomarkers
0
CD163 antigen
0
Collagen Type I
0
Procollagen
0
Receptors, Cell Surface
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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