Genetic Correlates of Fatigue in Individuals with End Stage Renal Disease.
depression
end stage renal disease
fatigue
gene expression
hemodialysis
Journal
Western journal of nursing research
ISSN: 1552-8456
Titre abrégé: West J Nurs Res
Pays: United States
ID NLM: 7905435
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
21
5
2020
medline:
14
8
2021
entrez:
21
5
2020
Statut:
ppublish
Résumé
Fatigue is a prevalent symptom associated with decreased quality of life and increased mortality in individuals with end stage renal disease (ESRD), yet causes of fatigue in individuals with ESRD remain poorly understood. We examined gene expression of Neuronal PAS Domain Protein 2 (NPAS2) in relation to patient-reported fatigue in 122 individuals with ESRD. Independent samples t-tests were used to examine NPAS2 gene expression profiles of: non-fatigue versus fatigue. Multivariable regression analyses were used to examine the relationship between fatigue and numerous variables including depression. Participants were approximately 58 years old (+/- 13.2 years), 78% African American (
Identifiants
pubmed: 32431239
doi: 10.1177/0193945920919911
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
NPAS2 protein, human
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM