The WorldWide Antimalarial Resistance Network Clinical Trials Publication Library: A Live, Open-Access Database of
Antimalarials
/ therapeutic use
Clinical Trials as Topic
Databases, Bibliographic
Databases, Factual
Drug Resistance
Drug Therapy, Combination
Humans
Malaria
/ drug therapy
Malaria, Falciparum
/ drug therapy
Malaria, Vivax
/ drug therapy
Plasmodium
/ physiology
Plasmodium falciparum
/ physiology
Plasmodium knowlesi
/ physiology
Plasmodium malariae
/ physiology
Plasmodium ovale
/ physiology
Plasmodium vivax
/ physiology
Journal
The American journal of tropical medicine and hygiene
ISSN: 1476-1645
Titre abrégé: Am J Trop Med Hyg
Pays: United States
ID NLM: 0370507
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
21
5
2020
medline:
29
8
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
Parasite resistance to antimalarial drugs poses a serious threat to malaria control. The WorldWide Antimalarial Resistance Network (WWARN) aims to provide a collaborative platform to support the global malaria research effort. Here, we describe the "WWARN clinical trials publication library," an open-access, up-to-date resource to streamline the synthesis of antimalarial safety and efficacy data. A series of iteratively refined database searches were conducted to identify prospective clinical trials assessing antimalarial drug efficacy with at least 28 days of follow-up. Of approximately 45,000 articles screened, 1,221 trials published between 1946 and 2018 were identified, representing 2,339 treatment arms and 323,819 patients. In trials from endemic locations, 75.7% (787/1,040) recruited patients with
Identifiants
pubmed: 32431267
doi: 10.4269/ajtmh.19-0706
pmc: PMC7356478
pii: tpmd190706
doi:
pii:
Substances chimiques
Antimalarials
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-368Références
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