Epidemiology of Intravitreal Injections in Iran: Indications and Referral Patterns in a Tertiary Hospital.
diabetes
epidemiology
indications
intravitreal injection
referral patterns
retinopathy of prematurity
Journal
Clinical ophthalmology (Auckland, N.Z.)
ISSN: 1177-5467
Titre abrégé: Clin Ophthalmol
Pays: New Zealand
ID NLM: 101321512
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
03
2020
accepted:
21
04
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
To study the relative contribution of major indications and geographic referral patterns for intravitreal bevacizumab injections in a tertiary hospital. In this retrospective study, hospital electronic registry was used to categorize patients who had received intravitreal injections (IVIs) during the 2014-2016 period into different groups based on indications. Relative contribution of each indication and odds of being resident of provinces other than Tehran were determined. The most prevalent indications for IVI were pathologies related to diabetes mellitus (DM) followed by choroidal neovascularization (CNV)/age-related macular degeneration (AMD) and retinal venous occlusion (RVO)-related complications. From 38,043 patients, 61.8% were residents of Tehran province. Patients in the CNV/AMD group were the oldest. Patients from Tehran province were significantly older (62.44 ±11.42 (12-99)) than patients who were referred from other provinces (59.23 ±11.39 (11-102)) (p=< 0.001). The majority of patients in all indication categories were from Tehran province, except for patients with retinopathy of prematurity (ROP). Odds of being referred from outside Tehran province for the ROP group compared to the DM-related, CNV/AMD, RVO-related and miscellaneous groups were 3.32, 4.27, 3.13 and 2.83, respectively (p<0.001). DM-related ocular complications outnumber all other indications of IVIs combined. Considering the preventable nature of these complications, efficient health policies can significantly reduce the burden of IVIs in Iran. The contribution of each indication category in overall burden of IVIs seems to vary considerably between different countries which merits further studies. The disproportionately high ratio of ROP patients who are referred from other provinces to the capital province for treatment indicates a suboptimal distribution of ROP care services throughout the country.
Identifiants
pubmed: 32431488
doi: 10.2147/OPTH.S256317
pii: 256317
pmc: PMC7200222
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1201-1206Informations de copyright
© 2020 Zarei et al.
Déclaration de conflit d'intérêts
None of the authors have any proprietary interests or conflicts of interest related to this submission.
Références
N Engl J Med. 2006 Oct 5;355(14):1419-31
pubmed: 17021318
Ophthalmology. 2012 Dec;119(12):2587-91
pubmed: 22902212
Diabetes Care. 2014;37(1):9-16
pubmed: 24356592
Ophthalmology. 2012 Apr;119(4):789-801
pubmed: 22330964
Ophthalmol Retina. 2018 Sep;2(9):942-948
pubmed: 31047228
Retina. 2008 Jun;28(6):831-8
pubmed: 18536599
Curr Med Res Opin. 2016 Dec;32(12):1943-1950
pubmed: 27494692
N Engl J Med. 2004 Dec 30;351(27):2805-16
pubmed: 15625332
Retina. 2019 Oct;39(10):2004-2011
pubmed: 30312260
Int J Appl Basic Med Res. 2012 Jul;2(2):92-6
pubmed: 23776819
CMAJ. 2014 Sep 16;186(13):1012-4
pubmed: 24958841