Usefulness of venoarterial extracorporeal membranous oxygenation for fatal cibenzoline succinate poisoning.
Cardiopulmonary arrest
cibenzoline succinate
direct hemoperfusion
extracorporeal membranous oxygenation
poisoning
Journal
Acute medicine & surgery
ISSN: 2052-8817
Titre abrégé: Acute Med Surg
Pays: United States
ID NLM: 101635464
Informations de publication
Date de publication:
Historique:
received:
18
10
2019
revised:
21
02
2020
accepted:
03
03
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
21
5
2020
Statut:
epublish
Résumé
The effect of venoarterial extracorporeal membranous oxygenation (V-A ECMO), plasma exchange (PE), and direct hemoperfusion (DHP) for fatal cibenzoline succinate poisoning is unclear. We report a rare case of severe cibenzoline succinate poisoning along with cardiac arrest, wherein the patient was managed with V-A ECMO, PE, and DHP. We also measured the blood levels of cibenzoline succinate frequently. A 51-year-old woman had a refractory cardiac arrest after cibenzoline succinate ingestion. We initiated V-A ECMO, PE, and DHP. Plasma exchange did not improve clinical manifestations. Her clinical condition improved during DHP, but there was no evidence about removal of drugs. On day 3, DHP and ECMO were terminated. On day 9, she was transferred to another hospital without arrhythmia recurrence. Venoarterial ECMO is effective in cases of cibenzoline succinate poisoning-related cardiac dysfunction or cardiac arrest. No evidence was obtained for the effects of PE and DHP.
Sections du résumé
BACKGROUND
BACKGROUND
The effect of venoarterial extracorporeal membranous oxygenation (V-A ECMO), plasma exchange (PE), and direct hemoperfusion (DHP) for fatal cibenzoline succinate poisoning is unclear. We report a rare case of severe cibenzoline succinate poisoning along with cardiac arrest, wherein the patient was managed with V-A ECMO, PE, and DHP. We also measured the blood levels of cibenzoline succinate frequently.
CASE PRESENTATION
METHODS
A 51-year-old woman had a refractory cardiac arrest after cibenzoline succinate ingestion. We initiated V-A ECMO, PE, and DHP. Plasma exchange did not improve clinical manifestations. Her clinical condition improved during DHP, but there was no evidence about removal of drugs. On day 3, DHP and ECMO were terminated. On day 9, she was transferred to another hospital without arrhythmia recurrence.
CONCLUSION
CONCLUSIONS
Venoarterial ECMO is effective in cases of cibenzoline succinate poisoning-related cardiac dysfunction or cardiac arrest. No evidence was obtained for the effects of PE and DHP.
Identifiants
pubmed: 32431847
doi: 10.1002/ams2.507
pii: AMS2507
pmc: PMC7231569
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e507Informations de copyright
© 2020 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine.
Déclaration de conflit d'intérêts
Approval of the protocol: N/A. Informed consent: Informed consent was obtained from the patient. Registry and the registration no. of the study/trial: N/A. Animal studies: N/A. Data sharing and accessibility: N/A. Conflict of interest: None.
Références
J Toxicol Clin Toxicol. 1999;37(4):505-8
pubmed: 10465249
Interact Cardiovasc Thorac Surg. 2010 Jul;11(1):95-7
pubmed: 20421279
J Med Toxicol. 2016 Mar;12(1):95-9
pubmed: 26013746
J Med Toxicol. 2019 Jul;15(3):169-177
pubmed: 30895517