Controlled release of basic fibroblast growth factor from a peptide biomaterial for bone regeneration.

bFGF bone mesenchymal stem cells porous nHA/PA66 self-assembling peptide sustained release

Journal

Royal Society open science
ISSN: 2054-5703
Titre abrégé: R Soc Open Sci
Pays: England
ID NLM: 101647528

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 17 10 2019
accepted: 12 02 2020
entrez: 21 5 2020
pubmed: 21 5 2020
medline: 21 5 2020
Statut: epublish

Résumé

Self-assembled peptide scaffolds based on D-RADA16 are an important matrix for controlled drug release and three-dimensional cell culture. In this work, D-RADA16 peptide hydrogels were coated on artificial bone composed of nano-hydroxyapatite/polyamide 66 (nHA/PA66) to obtain a porous drug-releasing structure for treating bone defects. The developed materials were characterized via transmission electron microscopy and scanning electron microscopy. The proliferation and adhesion of bone mesenchymal stem cells (BMSCs) were examined by confocal laser microscopy and CCK-8 experiments. The osteogenic ability of the porous materials towards bone BMSCs was examined

Identifiants

pubmed: 32431879
doi: 10.1098/rsos.191830
pii: rsos191830
pmc: PMC7211882
doi:

Banques de données

figshare
['10.6084/m9.figshare.c.4902408']
Dryad
['10.5061/dryad.td2p55f']

Types de publication

Journal Article

Langues

eng

Pagination

191830

Informations de copyright

© 2020 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interests.

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Auteurs

WeiKang Zhao (W)

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
Department of Orthopaedics, Third Affiliated Hospital of Chongqing Medical University, No. 1 Shuanghu Road, Chongqing City, Yubei District 401120, People's Republic of China.

Yuling Li (Y)

Department of Orthopaedics, Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Nanchong City, Sichuan Province 637000, People's Republic of China.

Ao Zhou (A)

Department of Orthopaedics, Third Affiliated Hospital of Chongqing Medical University, No. 1 Shuanghu Road, Chongqing City, Yubei District 401120, People's Republic of China.

Xiaojun Chen (X)

Department of Orthopaedics, Hospital (T.C.M) Affiliated to Southwest Medical University, No. 182 Chunhui Road, Luzhou City, Sichuan Province, 646000, People's Republic of China.

Kai Li (K)

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
Department of Orthopaedics, Third Affiliated Hospital of Chongqing Medical University, No. 1 Shuanghu Road, Chongqing City, Yubei District 401120, People's Republic of China.

Sinan Chen (S)

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
Department of Orthopaedics, Third Affiliated Hospital of Chongqing Medical University, No. 1 Shuanghu Road, Chongqing City, Yubei District 401120, People's Republic of China.

Bo Qiao (B)

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.

Dianming Jiang (D)

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
Department of Orthopaedics, Third Affiliated Hospital of Chongqing Medical University, No. 1 Shuanghu Road, Chongqing City, Yubei District 401120, People's Republic of China.

Classifications MeSH