In Search of Reward Deficiency Syndrome (RDS)-free Controls: The "Holy Grail" in Genetic Addiction Risk Testing.

Behavioral genetic research Reward Deficiency Syndrome (RDS) Single Nucleotide Polymorphisms (SNPs) case controlled studies genetic addiction association studies genetic prevalence hypodopaminergia study controls super controls

Journal

Current psychopharmacology
ISSN: 2211-5560
Titre abrégé: Curr Psychopharmacol
Pays: United Arab Emirates
ID NLM: 101610773

Informations de publication

Date de publication:
2020
Historique:
entrez: 21 5 2020
pubmed: 21 5 2020
medline: 21 5 2020
Statut: ppublish

Résumé

The search for an accurate, gene-based test to identify heritable risk factors for Reward Deficiency Syndrome (RDS) was conducted based on hundreds of published studies about the role of dopamine in addictive behaviors, including risk for drug dependence and compulsive/impulsive behavior disorders. The term RDS was first coined by Blum's group in 1995 to identify a group of behaviors with a common neurobiological mechanism associated with a polymorphic allelic propensity for hypodopaminergia. To outline the process used to select risk alleles of reward genes for the Genetic Addiction Risk Score (GARS) test. Consequently, to address the limitations caused by inconsistent results that occur in many case-control behavioral association studies. These limitations are perhaps due to the failure of investigators to adequately screen controls for drug and alcohol use disorder, and any of the many RDS behaviors, including nicotine dependence, obesity, pathological gambling, and internet gaming addiction. Review of the literature related to the function of risk alleles of reward genes associated with hypodopaminergia relevant case-control association studies for the selection of alleles to be measured by the Genetic Addiction Risk Score (GARS) test. The prevalence of the DRD2 A1 allele in unscreened controls (33.3%), compared to "Super-Controls" [highly screened RDS controls (3.3%) in proband and family] is used to exemplify a possible solution. Unlike one gene-one disease (OGOD), RDS is polygenetic, and very complex. In addition, any RDS-related behaviors must be eliminated from the control group in order to obtain the best possible statistical analysis instead of comparing the phenotype with disease-ridden controls.

Sections du résumé

BACKGROUND BACKGROUND
The search for an accurate, gene-based test to identify heritable risk factors for Reward Deficiency Syndrome (RDS) was conducted based on hundreds of published studies about the role of dopamine in addictive behaviors, including risk for drug dependence and compulsive/impulsive behavior disorders. The term RDS was first coined by Blum's group in 1995 to identify a group of behaviors with a common neurobiological mechanism associated with a polymorphic allelic propensity for hypodopaminergia.
OBJECTIVES OBJECTIVE
To outline the process used to select risk alleles of reward genes for the Genetic Addiction Risk Score (GARS) test. Consequently, to address the limitations caused by inconsistent results that occur in many case-control behavioral association studies. These limitations are perhaps due to the failure of investigators to adequately screen controls for drug and alcohol use disorder, and any of the many RDS behaviors, including nicotine dependence, obesity, pathological gambling, and internet gaming addiction.
METHODS METHODS
Review of the literature related to the function of risk alleles of reward genes associated with hypodopaminergia relevant case-control association studies for the selection of alleles to be measured by the Genetic Addiction Risk Score (GARS) test.
RESULTS RESULTS
The prevalence of the DRD2 A1 allele in unscreened controls (33.3%), compared to "Super-Controls" [highly screened RDS controls (3.3%) in proband and family] is used to exemplify a possible solution.
CONCLUSION CONCLUSIONS
Unlike one gene-one disease (OGOD), RDS is polygenetic, and very complex. In addition, any RDS-related behaviors must be eliminated from the control group in order to obtain the best possible statistical analysis instead of comparing the phenotype with disease-ridden controls.

Identifiants

pubmed: 32432025
pmc: PMC7236426
mid: NIHMS1587040

Types de publication

Journal Article

Langues

eng

Pagination

7-21

Subventions

Organisme : CSRD VA
ID : I01 CX000479
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073884
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH073624
Pays : United States
Organisme : NIMHD NIH HHS
ID : R41 MD012318
Pays : United States

Déclaration de conflit d'intérêts

CONFLICT OF INTEREST Dr. Blum is the inventor of GARS and along with Dr. Siwicki own Geneus Health. Lisa Lott and Jessica Ponce are paid by Geneus Health.

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Auteurs

Kenneth Blum (K)

Graduate School of Biomedical Science, Western University Health Sciences, Pomona, CA, USA.
Eotvos Loránd University, Institute of Psychology, Budapest, Hungary.
Department of Psychiatry, Wright State University Boonshoft School of Medicine and Dayton VA Medical Center, Dayton, OH, USA.
Department of Psychiatry, University of Vermont, Burlington, VT, USA.
Division of Clinical Neurology, PATH Foundation, New York, NY, USA.
Dominion Diagnostics, North Kingston, RI, USA.
Division of Precision Addiction Management, Geneus Health, San Antonio, TX, USA.
Division of Neuroscience & Addiction Therapy Research, Pathway HealthCare, Birmingham, AL, USA.
Victory Nutrition International, Inc., Lederach, PA, USA.

David Baron (D)

Graduate School of Biomedical Science, Western University Health Sciences, Pomona, CA, USA.

Lisa Lott (L)

Division of Precision Addiction Management, Geneus Health, San Antonio, TX, USA.

Jessica V Ponce (JV)

Division of Precision Addiction Management, Geneus Health, San Antonio, TX, USA.

David Siwicki (D)

Division of Precision Addiction Management, Geneus Health, San Antonio, TX, USA.

Brent Boyett (B)

Division of Neuroscience & Addiction Therapy Research, Pathway HealthCare, Birmingham, AL, USA.

Bruce Steinberg (B)

Department of Psychology, Curry College, Milton, MA, USA.

Edward J Modestino (EJ)

Department of Psychology, Curry College, Milton, MA, USA.

Lyle Fried (L)

Transformations Treatment Center, Delray Beach, FL, USA.

Mary Hauser (M)

Dominion Diagnostics, North Kingston, RI, USA.

Thomas Simpatico (T)

Department of Psychiatry, University of Vermont, Burlington, VT, USA.

Bill W Downs (BW)

Victory Nutrition International, Inc., Lederach, PA, USA.

Thomas McLaughlin (T)

Center for Psychiatric Medicine, Lawrence, MA, USA.

Raju Hajela (R)

Department of Family Medicine, Cummings School of Medicine, University of Calgary, Calgary, CN, Canada.

Rajendra D Badgaiyan (RD)

Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, and Long School of Medicine, University of Texas Medical Center, San Antonio, TX, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Classifications MeSH